Maladaptive plasticity in tinnitus—triggers, mechanisms and treatment

SE Shore, LE Roberts, B Langguth - Nature Reviews Neurology, 2016 - nature.com
Tinnitus is a phantom auditory sensation that reduces quality of life for millions of people
worldwide, and for which there is no medical cure. Most cases of tinnitus are associated with …

[HTML][HTML] An integrative tinnitus model based on sensory precision

W Sedley, KJ Friston, PE Gander, S Kumar… - Trends in …, 2016 - cell.com
Tinnitus is a common disorder that often complicates hearing loss. Its mechanisms are
incompletely understood. Current theories proposing pathophysiology from the ear to the …

[HTML][HTML] Pathophysiology of subjective tinnitus: triggers and maintenance

HF Haider, T Bojić, SF Ribeiro, J Paço… - Frontiers in …, 2018 - frontiersin.org
Tinnitus is the conscious perception of a sound without a corresponding external acoustic
stimulus, usually described as a phantom perception. One of the major challenges for …

What's the buzz? The neuroscience and the treatment of tinnitus

A Henton, T Tzounopoulos - Physiological reviews, 2021 - journals.physiology.org
Tinnitus is a pervasive public health issue that affects∼ 15% of the United States population.
Similar estimates have also been shown on a global scale, with similar prevalence found in …

[HTML][HTML] Tinnitus: does gain explain?

W Sedley - Neuroscience, 2019 - Elsevier
Many, or most, tinnitus models rely on increased central gain in the auditory pathway as all
or part of the explanation, in that central auditory neurones deprived of their usual sensory …

[HTML][HTML] The hearing hippocampus

AJ Billig, M Lad, W Sedley, TD Griffiths - Progress in neurobiology, 2022 - Elsevier
The hippocampus has a well-established role in spatial and episodic memory but a broader
function has been proposed including aspects of perception and relational processing …

[HTML][HTML] Genetic architecture distinguishes tinnitus from hearing loss

RE Clifford, AX Maihofer, C Chatzinakos… - Nature …, 2024 - nature.com
Tinnitus is a heritable, highly prevalent auditory disorder treated by multiple medical
specialties. Previous GWAS indicated high genetic correlations between tinnitus and …

[HTML][HTML] Symptom dimensions to address heterogeneity in tinnitus

A Mohan, SL Leong, D De Ridder… - … & Biobehavioral Reviews, 2022 - Elsevier
Tinnitus, the auditory phantom percept, is a well-known heterogenous disorder with multiple
subtypes. Researchers and clinicians have tried to classify these subtypes according to …

Novel risk loci in tinnitus and causal inference with neuropsychiatric disorders among adults of European ancestry

RE Clifford, AX Maihofer, MB Stein… - … –Head & Neck …, 2020 - jamanetwork.com
Importance Tinnitus affects at least 16 million US adults, but its pathophysiology is
complicated, and treatment options remain limited. A heritable component has been …

[HTML][HTML] Sensory overamplification in layer 5 auditory corticofugal projection neurons following cochlear nerve synaptic damage

MM Asokan, RS Williamson, KE Hancock… - Nature …, 2018 - nature.com
Abstract Layer 5 (L5) cortical projection neurons innervate far-ranging brain areas to
coordinate integrative sensory processing and adaptive behaviors. Here, we characterize a …