Proteins are multifunctional large organic compounds that constitute an essential
component of a living system. Hence, control over their bioconjugation impacts science at …

The central dogma of modern biology underscores the pivotal roles proteins play in diverse
biological processes, the study of which necessitates advanced methods to produce …

The amidated peptides are an important class of biologically active compounds due to their
unique biological properties and wide applications as potential peptide drugs and …

Herein, we report a versatile reaction platform for tracelessly cleavable cysteine-selective
peptide/protein modification. This platform offers highly tunable and predictable conjugation …

Amino groups are common in both natural and synthetic compounds and offer a very
attractive class of endogenous handles for bioconjugation. However, the ability to …

Peptides act as biological mediators and play a key role of various physiological activities.
Sulfur-containing peptides are widely used in natural products and drug molecules due to …

Peptides are increasingly important drug candidates, offering numerous advantages over
conventional small molecules. However, they face significant challenges related to stability …

Abstract α‐Ketoaldehydes play versatile roles in the ubiquitous natural processes of protein
glycation. However, leveraging the reactivity of α‐ketoaldehydes for biomedical applications …

We report a minimalist gaseous sulfonyl-chloride-derived reagent for multicomponent
bioconjugation with amine, phenol, or aniline reagents to afford urea or carbamate products …

Visible-light-mediated methods were heavily studied as a useful tool for cysteine-selective
bio-conjugation; however, many current methods suffer from bio-incompatible reaction …