Systemic lupus erythematosus, Sjögren's syndrome, and dermatomyositis are systemic
autoimmune diseases that develop after environmental triggering of genetically susceptible …

Th17 cells that secrete the cytokines IL-17A and IL-17F and express lineage-specific
transcription factor RORC (RORγt in mice) represent a distinct lineage of CD4+ T cells …

Although the aetiology of systemic lupus erythematosus (SLE) is unclear, dysregulated B
cell responses have been implicated. Here we show that an unusual CD11chiT-bet+ B cell …

Systemic lupus erythematosus (SLE) is an autoimmune disease with marked gender and
ethnic disparities. We report a large transancestral association study of SLE using …

T helper 17 (Th17) cells belong to a recently identified T helper subset, in addition to the
traditional Th1 and Th2 subsets. These cells are characterized as preferential producers of …

Abnormalities in B cells play pivotal roles in the pathogenesis of systemic lupus
erythematosus (SLE) and lupus nephritis (LN). Breach in central and peripheral tolerance …

During our life, we are surrounded by continuous threats from a diverse range of invading
pathogens. Our immune system has evolved multiple mechanisms to efficiently deal with …

Interleukin (IL)-2, IL-4, IL-7, IL-9, IL-15, and IL-21 form a family of cytokines based on their
sharing the common cytokine receptor γ chain (γc), which was originally discovered as the …

Cytokines are key instigators and regulators of immune responses and therefore hold great
potential as targets for new therapeutic strategies. However, the selection of which cytokines …

Systemic lupus erythematosus (SLE) is an autoimmune disease of unknown origin affecting
virtually all organ systems. Beyond genetic and environmental factors, cytokine imbalances …