Metabolic reprogramming, including enhanced biosynthesis of macromolecules, altered
energy metabolism, and maintenance of redox homeostasis, is considered a hallmark of …

Phosphatase and tensin homolog deleted on chromosome ten (PTEN) is a phosphatase that
is frequently altered in cancer. PTEN has phosphatase-dependent and-independent roles …

Ubiquitination is one of the posttranslational modifications that regulates a number of
intracellular events including signal transduction, protein quality control, transcription, cell …

Pathological Unfoldomics of Uncontrolled Chaos: Intrinsically Disordered Proteins and Human
Diseases | Chemical Reviews ACS ACS Publications C&EN CAS Find my institution Log In …

Oncogenic signaling involved in tumor metabolic reprogramming. Tumorigenesis was not
only determined by the mutations or deletion of oncogenes but also accompanied by the …

Tumor suppressor activation or reactivation has long been a sought-after, yet elusive,
therapeutic strategy for human cancer. Phosphatase and tensin homolog (PTEN) is one of …

Simple Summary Cancer cells accumulate genetic alterations that improve their
proliferation, survival, and migration capabilities. One of the most frequently altered …

The role of phosphatase and tensin homolog on chromosome 10 (PTEN) as a tumor
suppressor has been for a long time attributed to its lipid phosphatase activity against PI (3 …

PTEN is one of the most frequently mutated tumour suppressors and reduction in PTEN
protein stability also plays a role in tumorigenesis. Although several ubiquitin ligases for …

Ubiquitination displays a crucial role in various biological functions, such as protein
degradation, signal transduction, and cellular homeostasis. Accumulating evidence has …