Loop dynamics and the evolution of enzyme activity

M Corbella, GP Pinto, SCL Kamerlin - Nature Reviews Chemistry, 2023 - nature.com
In the early 2000s, Tawfik presented his 'New View'on enzyme evolution, highlighting the
role of conformational plasticity in expanding the functional diversity of limited repertoires of …

Protein loop modeling using Alphafold2

J Wang, W Wang, Y Shang - IEEE/ACM Transactions on …, 2023 - ieeexplore.ieee.org
The functions of proteins are largely determined by their three-dimensional (3D) structures.
Loop modeling tries to predict the conformation of a relatively short stretch of protein …