Opioid use disorder (OUD) is a major current cause of morbidity and mortality. Long-term
exposure to short-acting opioids (MOP-r agonists such as heroin or fentanyl) results in …

This paper is the forty-fifth consecutive installment of the annual anthological review of
research concerning the endogenous opioid system, summarizing articles published during …

Dynamic interactions of neurons and glia in the ventral midbrain mediate reward and
addiction behavior. We studied gene expression in 212,713 ventral midbrain single nuclei …

Addiction is a leading cause of disease burden worldwide and remains a challenge in
current neuroscience research. Drug-induced lasting changes in gene expression are …

The prevention and treatment of addiction (moderate to severe substance use disorder—
SUD) have remained challenging because of the dynamic and complex interactions …

Objective Nausea and vomiting remain life-threatening obstacles to successful treatment of
chronic diseases, despite a cadre of available antiemetic medications. Our inability to …

Preclinical models of addictive drugs have been developed for decades to model aspects of
the clinical experience in substance use disorders (SUDs). These include passive exposure …

The development of single-cell and single-nucleus transcriptome technologies is enabling
the unraveling of the molecular and cellular heterogeneity of psychiatric disorders. The …

Opioid misuse, addiction, and associated overdose deaths remain global public health
crises. Despite the tremendous need for pharmacological treatments, current options are …

The high rates of relapse associated with current medications used to treat opioid use
disorder (OUD) necessitate research that expands our understanding of the neural …