Abstract The Epidermal Growth Factor Receptor (EGFR) is frequently expressed at elevated
levels in different forms of cancer and expression often correlates positively with cancer …

Cancer cell dormancy is a common feature of human tumors and represents a major clinical
barrier to the long-term efficacy of anticancer therapies. Dormant cancer cells, either in …

Aim In this review, we have attempted to provide the readers with an updated account of the
role of a family of proteins known as E3 ligases in different aspects of lung cancer …

Drug therapy is the primary treatment for patients with advanced cancer. The use of
anticancer drugs will inevitably lead to drug resistance, which manifests as tumor …

Cancer is a complex heterogenic disease with significant therapeutic challenges. The
presence of cancer stem cells (CSCs) in cancer tissue orchestrates tumor growth …

Tumor therapeutics often target the primary tumor bulk but fail to eradicate therapy-resistant
cancer stem cells (CSCs) in quiescent state. These can then become activated to initiate …

SCFFBXW7 E3 ubiquitin ligase complex is a crucial enzyme of the ubiquitin proteasome
system that participates in variant activities of cell process, and its component FBXW7 (F-box …

FBXW7, a member of the F-box protein family within the ubiquitin–proteasome system,
performs an indispensable role in orchestrating cellular processes through ubiquitination …

Tumor recurrence is a mechanism triggered in sparse populations of cancer cells that
usually remain in a quiescent state after strict stress and/or therapeutic factors, which is …

F-box and WD repeat domain-containing 7 (FBXW7), formerly known as hCdc4, hAGO
Fbw7, or SEL10, plays a specific recognition function in SCF-type E3 ubiquitin ligases …