Highlights•Both Polycomb and constitutive heterochromatin components undergo phase
separation.•HP1 drives the formation of condensed structures that contribute to silencing …

Chromatin undergoes dynamic regulation through reversible histone post-translational
modifications (PTMs), orchestrated by “writers,”“erasers,” and “readers” enzymes …

In mammalian oocytes, large-scale chromatin organization regulates transcription, nuclear
architecture, and maintenance of chromosome stability in preparation for meiosis onset. Pre …

Establishing, maintaining, and removing histone post-translational modifications associated
with heterochromatin is critical for shaping genomic structure and function as a cell …

During cell division, drastic cellular changes characteristic of mitosis result in the inactivation
of the transcriptional machinery, and global downregulation of transcription. Sequence …

The fixation and permeabilization of cells are essential for labeling intracellular biomarkers
in flow cytometry. However, these chemical treatments often alter fragile targets, such as cell …

In eukaryotic nuclei, DNA is wrapped around an octamer of core histones to form
nucleosomes. H1 binds to the linker DNA of nucleosome to form the chromatosome, the next …

Dinoflagellate birefringent chromosomes (BfCs) contain some of the largest known
genomes, yet they lack typical nucleosomal micrococcal-nuclease protection patterns …

The last edition of the X-chromosome inactivation (XCI) meeting was held as an EMBO
workshop in Berlin on 19-22 June 2023. The conference took place at the Harnack-haus in …

Genome organization and the three-dimensional folding of chromosomes are now seen as
major contributors to nearly all nuclear functions including gene regulation, replication and …