Lactic acid is one of the most abundant products of cellular metabolism and has historically
been considered a cell-damaging metabolic product. However, as research has deepened …

Melatonin is synthesized in the pineal gland at night. Since melatonin is produced in the
mitochondria of all other cells in a non-circadian manner, the amount synthesized by the …

Neurons require large amounts of energy, but whether they can perform glycolysis or require
glycolysis to maintain energy remains unclear. Using metabolomics, we show that human …

Lactic acid bacteria (LAB) are a kind of Gram-positive bacteria which can colonize in the
biological gastrointestinal tract and play a variety of probiotic roles. LAB have a wide range …

Cancer is the second leading cause of death worldwide, with a dramatic impact due to the
acquired resistance of cancers to used chemotherapeutic drugs and treatments. The …

Cancer is one of the leading causes of mortality and morbidity worldwide. According to 2022
statistics from the World Health Organization (WHO), close to 10 million deaths have been …

Malignant mesothelioma (MM) is a highly aggressive and resistant tumor. The prognostic
role of key effectors of glycolytic metabolism in MM prompted our studies on the cytotoxicity …

Background and Objective. Adenovirus pneumonia is a severe disease in children.
Constructing a prognostic model contributes to individualized treatment of children with …

Background: Lactate dehydrogenase (LDH) is one of the important enzyme systems for
glycolysis and gluconeogenesis. It can catalyze the reduction and oxidation reaction …

The human gut hosts close to 4 trillion microorganisms, which is nearly equivalent to the
estimated 3.0× 1013 human cells in a 70 kg body. Although the composition of gut …