Collectively, the endothelins and their receptors—referred to as the endothelin (ET) axis—
have key physiological functions in normal tissue, acting as modulators of vasomotor tone …

Some of the most common human cancers, including breast cancer, prostate cancer, and
lung cancer, metastasize with avidity to bone. What is the basis for their preferential growth …

BACKGROUND Unlike most other malignancies, prostate cancer metastasizes preferentially
to the skeleton and elicits osteoblastic reactions. METHODS We present a hypothesis …

Osteoblastic bone metastases are common in prostate and breast cancer patients, but
mechanisms by which tumor cells stimulate new bone formation are unclear. We identified …

Advanced prostate cancer is frequently accompanied by the development of metastasis to
bone. In the past, prostate cancer bone metastases were characterized as being …

Tumor blood vessels supply nutrients and oxygen to tumor cells for their growth and provide
routes for them to enter circulation. Thus, angiogenesis, the formation of new blood vessels …

PURPOSE: To determine the activity and toxicity of doxorubicin in combination with cisplatin
and etoposide in patients with small-cell prostate carcinoma (SCPCa) and to characterize …

Endothelins are important mediators of physiological and pathophysiologic processes
including cardiovascular disorders, pulmonary disease, renal diseases and many others …

Prostate cancer is a complex disease in which metastasis to the bone is the main cause of
death. Initial stages of metastasis are generally similar to those for most solid tumors; …

Abstract Endothelin-1 (ET-1) is a 21 amino acid peptide with diverse biological activity that
has been implicated in numerous diseases. ET-1 is a potent mitogen regulator of smooth …