Biomaterials and bioactive natural products from marine invertebrates: From basic research to innovative applications

G Romano, M Almeida, A Varela Coelho, A Cutignano… - Marine Drugs, 2022 - mdpi.com
Aquatic invertebrates are a major source of biomaterials and bioactive natural products that
can find applications as pharmaceutics, nutraceutics, cosmetics, antibiotics, antifouling …

Mechanisms of cancer cell killing by sea cucumber-derived compounds

TL Wargasetia, Widodo - Investigational New Drugs, 2017 - Springer
The aim of cancer therapy is to specifically eradicate tumor cells while causing minimal
damage to normal tissues and minimal side-effects. Because of this, the use of natural …

[PDF][PDF] Chemical biodiversity and bioactivities of Saponins in Echinodermata with an emphasis on sea cucumbers (Holothuroidea)

E Kamyab, MY Kellermann, A Kunzmann… - YOUMARES 9-the …, 2020 - library.oapen.org
Echinoderms are a source of a broad range of secondary metabolites with a large variety of
bioactive properties. Although pigment and lipid derivatives are the major groups of …

Anti-proliferative and anti-inflammatory activities of the sea cucumber Holothuria polii aqueous extract

M Kareh, R El Nahas, L Al-Aaraj… - SAGE Open …, 2018 - journals.sagepub.com
Objective: Sea cucumbers are considered among the most important functional foods.
Following bioassay guided fractionation, we assessed the anti-proliferative and anti …

Bioactive compounds of sea cucumbers and their therapeutic effects

S Shi, W Feng, S Hu, S Liang, N An, Y Mao - Chinese Journal of …, 2016 - Springer
Sea cucumbers belong to the Class Holothuroidea of marine invertebrates. They are
commercially valuable and prized as a food and folk medicine in Asia. Nutritionally, sea …

Chemotaxonomic study of the most abundant Egyptian sea-cucumbers using ultra-performance liquid chromatography (UPLC) coupled to high-resolution mass …

NE Omran, HK Salem, SH Eissa, AM Kabbash… - Chemoecology, 2020 - Springer
Actinopyga maur itiana, Bohadschia marmorata, Holothuria leucospilota, H. edulis, H. atra
and H. polii are the abundant sea-cucumbers inhabiting either Red or Mediterranean Sea …

Holothuria scabra Extract Induces Cell Apoptosis and Suppresses Warburg Effect by Down-Regulating Akt/mTOR/HIF-1 Axis in MDA-MB-231 Breast Cancer Cells

L Yurasakpong, S Apisawetakan… - Nutrition and …, 2021 - Taylor & Francis
Introduction Cancer cells utilize the modified glucose metabolism known as Warburg effect,
with lactate production as the end product. In the search for alternative therapy, the body …

[PDF][PDF] LC-HRMS based approach for identification and quantification analysis of chemical constituents of sea cucumbers from aegean sea-their cytotoxic and antiviral …

NB Sarikahya, GS Okkali, D Gunay, AC Goren… - Nat. Prod, 2022 - acgpubs.org
Figure S1: Collecting area of sea cucumbers 2 Table S1: Mass parameters and linear
regression equation of compounds. 3 Figure S2: Viability of S. regalis against the cell lines 4 …

The role of sea cucumber active compound and its derivative as an anti-cancer agent

TL Wargasetia, S Permana, Widodo - Current Pharmacology Reports, 2018 - Springer
Abstract Purpose of Review This article gives a brief overview on the role of sea cucumber
active compounds in cancer cell killing that may be developed into a potent anti-cancer …

[PDF][PDF] Extract of the sea cucumber, Holothuria scabra, induces apoptosis in human glioblastoma cell lines

K Sangpairoj, K Chaithirayanon… - Funct. Foods Health …, 2016 - academia.edu
Background: Glioblastoma is the most aggressive primary brain tumor resistant to
conventional treatment, and has a frequent recurrence. Holothuria scabra is the most widely …