Epigenetic mechanisms act to change the accessibility of chromatin to transcriptional
regulation locally and globally via modifications of the DNA and by modification or …

Epigenetic regulation of gene expression is mediated through alterations in the DNA
methylation status, covalent modifications of core nucleosomal histones, rearrangement of …

The proto-oncogene EVI1 encodes a DNA binding protein and is located on chromosome
3q26. The gene is aberrantly expressed in acute myeloid leukemia (AML) patients carrying …

Alterations of the ets family transcription factor ETV6 (TEL) and the RUNT domain
transcription factor RUNX1 (AML1) play pivotal roles in the leukemogenesis of various types …

Evi1 (ecotropic viral integration site 1) is essential for proliferation of hematopoietic stem
cells and implicated in the development of myeloid disorders. Particularly, high Evi1 …

Myelodysplasia is a hematological disease in which genomic abnormalities accumulate in a
hematopoietic stem cell leading to severe pancytopenia, multilineage differentiation …

Retroviruses can induce hematopoietic disease via insertional mutagenesis of cancer genes
and provide valuable molecular tags for cancer gene discovery. Here we show that …

The EVI1 gene codes for a zinc finger transcription factor with important roles both in normal
development and in leukemogenesis. Transcriptional activation of this gene through …

The histone methyltransferase Mixed Lineage Leukemia (MLL) is essential to maintain
hematopoietic stem cells and is a leukemia protooncogene. Although clustered homeobox …

Cytogenetic abnormalities are seen in approximately 50% of cases of myelodysplastic
syndrome (MDS) and 80% of cases of secondary MDS (following chemotherapy or …