Background Pulmonary route is an attractive target for both systemic and local drug delivery,
with the advantages of a large surface area, rich blood supply, and absence of first-pass …

Introduction Drugs delivered via the lungs are predominantly used to treat various
respiratory disorders, including asthma, chronic obstructive pulmonary diseases, respiratory …

Introduction: Pulmonary arterial hypertension (PAH) is a progressive disease characterized
by remodeling of small pulmonary arteries leading to increased pulmonary arterial pressure …

Lungs experience frequent interactions with the external environment and have an
abundant supply of blood; therefore, they are susceptible to invasion by pathogenic …

Drug repurposing with novel strategies has substantially contributed to the identification and
analysis of new molecules for better pulmonary intervention. This review would offer insights …

Many patients with multiple myeloma (MM) have comorbidities and are treated with PPAR
agonists. Immunomodulatory agents (IMiDs) are the cornerstones for MM therapy. Currently …

Recent advances in aging research have provided novel insights for the development of
senotherapy, which utilizes cellular senescence as a therapeutic target. Cellular …

Significance: Peroxisome proliferator-activated receptor-gamma (PPARγ) maintains
pulmonary vascular health through coordination of antioxidant defense systems …

BACKGROUND: Hyperproliferation of pulmonary arterial smooth muscle cells (PASMCs)
and consequent pulmonary vascular remodeling are the crucial pathological features of …

Pulmonary arterial hypertension (PAH) is a rare, serious, and incurable disease
characterized by high lung pressure. PAH-approved drugs based on conventional pathways …