Preeclampsia evolves in 2 stages: a placental problem that generates signals to the mother
to cause a range of responses that comprise the second stage (preeclampsia syndrome) …

The concept that preeclampsia is a multisystemic syndrome is appreciated in both research
and clinical care. Our understanding of pathophysiology recognizes the role of inflammation …

Hypertensive disorders of pregnancy affect up to 10% of pregnancies worldwide, which
includes the 3%–5% of all pregnancies complicated by preeclampsia. Preeclampsia is …

The pharmacokinetics of vitamin C (vitC) is indeed complex. Regulated primarily by a family
of saturable sodium dependent vitC transporters (SVCTs), the absorption and elimination …

Vitamin C (Ascorbic Acid), the antiscorbutic vitamin, cannot be synthesized by humans and
other primates, and has to be obtained from diet. Ascorbic acid is an electron donor and acts …

The role of oxidative stress in the physiopathology of human pregnancy is of particular
interest. Pregnancy is well-known to increase the oxidative stress, mainly produced by a …

Background Existing evidence on the effects of race and ethnicity on pregnancy outcomes is
restricted to individual studies done within specific countries and health systems. We aimed …

Preeclampsia is diagnosed in women presenting with new onset hypertension accompanied
by proteinuria or other signs of severe organ dysfunction in the second half of pregnancy …

The mechanistic properties of two dietary antioxidants that are required by humans, vitamins
C and E, are discussed relative to their biological effects. Vitamin C (ascorbic acid) is an …

Pre-eclampsia is a major cause of maternal mortality (15–20% in developed countries) and
morbidities (acute and long-term), perinatal deaths, preterm birth, and intrauterine growth …