HIV superinfection occurs when an individual with HIV is infected with a new distinct HIV
viral strain. Superinfection has been reported throughout the world, and studies have …

Inhibitors that target the retroviral enzyme reverse transcriptase (RT) have played an
indispensable role in the treatment and prevention of HIV-1 infection. They can be grouped …

Abstract Background. Preexposure prophylaxis (PrEP) with emtricitabine plus tenofovir
disoproxil fumarate (FTC/TDF) or TDF alone reduces the risk of human immunodeficiency …

To address drug resistance to HIV-1 non-nucleoside reverse transcriptase inhibitors
(NNRTIs), a series of novel diarylpyrimidine (DAPY) derivatives targeting “tolerant region I” …

Although non-nucleoside reverse transcriptase inhibitors (NNRTIs) exhibit potent anti-HIV-1
activity and play an important role in the active antiretroviral therapy of AIDS, the emergence …

The hybrids of delavirdine and piperdin-4-yl-aminopyrimidine (DPAPYs) were designed
from two excellent HIV-1 NNRTIs delavirdine and piperidin-4-yl-aminopyrimidine via …

Technologic advances in human immunodeficiency virus type 1 (HIV-1) sequencing have
revolutionized the study of antiretroviral drug resistance and are increasingly moving from …

Our previous efforts have led to the development of two potent NNRTIs, K-5a2 and 25a,
exhibiting effective anti-HIV-1 potency and resistance profiles compared with etravirine …

To yield potent HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) with
favorable drug-like properties, a series of novel diarylpyrimidine derivatives targeting the …

Non-nucleoside reverse transcriptase inhibitors (NNRTIs) represent an indispensable part of
anti-HIV-1 therapy. To discover novel HIV-1 NNRTIs with increased drug resistance profiles …