[HTML][HTML] O-GlcNAcylation in tumorigenesis and its implications for cancer therapy
Abstract O-linked N-acetylglucosaminylation (O-GlcNAcylation) is a dynamic and reversible
posttranslational modification that targets serine and threonine residues in a variety of …
posttranslational modification that targets serine and threonine residues in a variety of …
Opportunities for Therapeutic Modulation of O-GlcNAc
SS Cheng, AC Mody, CM Woo - Chemical Reviews, 2024 - ACS Publications
O-Linked β-N-acetylglucosamine (O-GlcNAc) is an essential, dynamic monosaccharide post-
translational modification (PTM) found on serine and threonine residues of thousands of …
translational modification (PTM) found on serine and threonine residues of thousands of …
O-GlcNAc informatics: advances and trends
As a post-translational modification, protein glycosylation is critical in health and disease. O-
Linked β-N-acetylglucosamine (O-GlcNAc) modification (O-GlcNAcylation), as an …
Linked β-N-acetylglucosamine (O-GlcNAc) modification (O-GlcNAcylation), as an …
Exploring the landscape of post-translational modification in drug discovery
Y Cao, T Yu, Z Zhu, Y Zhang, S Sun, N Li, C Gu… - Pharmacology & …, 2024 - Elsevier
Post-translational modifications (PTMs) play a crucial role in regulating protein function, and
their dysregulation is frequently associated with various diseases. The emergence of …
their dysregulation is frequently associated with various diseases. The emergence of …
The non-catalytic domains of O-GlcNAc cycling enzymes present new opportunities for function-specific control
O-GlcNAcylation is an essential protein glycosylation governed by two O-GlcNAc cycling
enzymes: O-GlcNAc transferase (OGT) installs a single sugar moiety N-acetylglucosamine …
enzymes: O-GlcNAc transferase (OGT) installs a single sugar moiety N-acetylglucosamine …
Uncovering the intricacies of O-GlcNAc modification in cognitive impairment: New insights from regulation to therapeutic targeting
J Wang, N Jiang, F Liu, C Wang, W Zhou - Pharmacology & Therapeutics, 2024 - Elsevier
O-linked β-N-acetylglucosamine (O-GlcNAc) represents a post-translational modification that
occurs on serine or threonine residues on various proteins. This conserved modification …
occurs on serine or threonine residues on various proteins. This conserved modification …
Increased O-GlcNAcylation connects metabolic to transcriptional reprogramming during pathophysiological cell activation
Increased protein O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) has emerged as
a hallmark of mammalian cell activation, contributing to Warburg-like metabolic rewiring …
a hallmark of mammalian cell activation, contributing to Warburg-like metabolic rewiring …
Current Technologies Unraveling the Significance of Post-Translational Modifications (PTMs) as Crucial Players in Neurodegeneration
S Zafar, SI Fatima, M Schmitz, I Zerr - Biomolecules, 2024 - mdpi.com
Neurodegenerative disorders, such as Parkinson's disease, Alzheimer's disease, and
Huntington's disease, are identified and characterized by the progressive loss of neurons …
Huntington's disease, are identified and characterized by the progressive loss of neurons …
靶向编辑O-GlcNAc 糖基化修饰的化学生物学技术.
潘雅文， 王贞超， 沈大成 - Chinese Journal of Biochemistry & …, 2024 - search.ebscohost.com
摘要糖基化修饰是最丰富和最复杂的蛋白质翻译后修饰之一. 其中, 氧连⁃ N⁃
乙酰氨基葡萄糖基化修饰(O⁃ GlcNAcylation) 作为广泛存在于真核细胞质或线粒体的蛋白质糖 …
乙酰氨基葡萄糖基化修饰(O⁃ GlcNAcylation) 作为广泛存在于真核细胞质或线粒体的蛋白质糖 …
FTO O-GlcNAcylation induces inactive form Pyrin expression, which suppresses NLRP3 inflammasome activation during LPS stimulation
XL Zhang, L Zhang, M Liu, Y Xie, BF Yuan, Z Peng… - 2024 - researchsquare.com
The fat mass and obesity-associated protein (FTO), as a key RNA N6-methyladenosine
(m6A) demethylase, has been recently highlighted in modulating inflammatory response …
(m6A) demethylase, has been recently highlighted in modulating inflammatory response …