The adult skeleton is renewed by remodeling throughout life. Bone remodeling is a process
where osteoclasts and osteoblasts work sequentially in the same bone remodeling unit …

To treat systemic bone loss as in osteoporosis and/or focal osteolysis as in rheumatoid
arthritis or periodontal disease, most approaches target the osteoclasts, the cells that resorb …

Microglia are strongly implicated in the development and progression of Alzheimer's disease
(AD), yet their impact on pathology and lifespan remains unclear. Here we utilize a CSF1R …

This review describes the key discoveries over the last 15 years that have led to a clearer
understanding of the molecular mechanisms by which bisphosphonate drugs inhibit bone …

Bisphosphonates (BP) are a class of calcium-binding drug used to prevent bone resorption
in skeletal disorders such as osteoporosis and metastatic bone disease. They act by …

The ability of bisphosphonates ((HO) 2 P (O) CR 1 R 2 P (O)(OH) 2) to inhibit bone
resorption has been known since the 1960s, but it is only recently that a detailed molecular …

Abstract The bisphosphonates ((HO) 2 P (O) CR 1 R 2 P (O)(OH) 2, BPs) were first shown to
inhibit bone resorption in the 1960s, but it was not until 30 years later that a detailed …

Root amputation, extraction of a single tooth, bone loss or severe tooth mobility, and an
unclosed wound were significantly associated with increased risk of developing medication …

The high concentration of mineral present in bone and pathological calcifications is unique
compared with all other tissues and thus provides opportunity for targeted delivery of …

Four decades of preclinical and clinical research of the pharmacology of bisphosphonates
have generated data and concepts that have considerably improved their clinical use …