Spatial learning‐induced increase in agmatine levels at hippocampal CA1 synapses

B Leitch, O Shevtsova, K Reusch, DH Bergin, P Liu - Synapse, 2011 - Wiley Online Library
Agmatine, a metabolite of l‐arginine, is considered as a novel putative neurotransmitter. It
has been detected in axon terminals that synapse with pyramidal cells in the hippocampus …

Agmatine protects against β-amyloid25-35-induced memory impairments in the rat

DH Bergin, P Liu - Neuroscience, 2010 - Elsevier
Amyloid beta fragment 25-35 (Aβ25-35) is the neurotoxic domain of the full-length Aβ1-42
and causes memory impairments in rodents. Recent research suggests that agmatine …

Differential effects of icv microinfusion of agmatine on spatial working and reference memory in the rat

P Liu, DH Bergin - Neuroscience, 2009 - Elsevier
Recent evidence suggests that agmatine, the metabolite of arginine by arginine
decarboxylase, exists in the mammalian brain and is a novel neurotransmitter. Exogenous …

Pre-aggregated Aβ25–35 alters arginine metabolism in the rat hippocampus and prefrontal cortex

P Liu, Y Jing, ND Collie, SA Campbell, H Zhang - Neuroscience, 2011 - Elsevier
Amyloid beta (Aβ) has been proposed to play a central and causative role in the
development of Alzheimer's disease. Aβ25–35, the neurotoxic domain of the full-length Aβ …