Neonatal hypoxia ischaemia: mechanisms, models, and therapeutic challenges

LJ Millar, L Shi, A Hoerder-Suabedissen… - Frontiers in cellular …, 2017 - frontiersin.org
Neonatal hypoxia-ischaemia (HI) is the most common cause of death and disability in
human neonates, and is often associated with persistent motor, sensory, and cognitive …

Brain-immune interactions in perinatal hypoxic-ischemic brain injury

B Li, K Concepcion, X Meng, L Zhang - Progress in neurobiology, 2017 - Elsevier
Perinatal hypoxia-ischemia remains the primary cause of acute neonatal brain injury,
leading to a high mortality rate and long-term neurological deficits, such as behavioral …

MiRNA-210 induces microglial activation and regulates microglia-mediated neuroinflammation in neonatal hypoxic-ischemic encephalopathy

B Li, C Dasgupta, L Huang, X Meng… - Cellular & Molecular …, 2020 - nature.com
Neuroinflammation is a major contributor to secondary neuronal injury that accounts for a
significant proportion of final brain cell loss in neonatal hypoxic-ischemic encephalopathy …

Plasticity in the neonatal brain following hypoxic‐ischaemic injury

E Rocha-Ferreira, M Hristova - Neural plasticity, 2016 - Wiley Online Library
Hypoxic‐ischaemic damage to the developing brain is a leading cause of child death, with
high mortality and morbidity, including cerebral palsy, epilepsy, and cognitive disabilities …

Rodent hypoxia–ischemia models for cerebral palsy research: a systematic review

P Rumajogee, T Bregman, SP Miller, JY Yager… - Frontiers in …, 2016 - frontiersin.org
Cerebral palsy (CP) is a complex multifactorial disorder, affecting approximately 2.5–3/1000
live term births, and up to 22/1000 prematurely born babies. CP results from injury to the …

The potential role of ferroptosis in neonatal brain injury

Y Wu, J Song, Y Wang, X Wang, C Culmsee… - Frontiers in …, 2019 - frontiersin.org
Ferroptosis is an iron-dependent form of cell death that is characterized by early lipid
peroxidation and different from other forms of regulated cell death in terms of its genetic …

Insights into the neuroinflammatory responses after neonatal hypoxia-ischemia

M Ziemka-Nalecz, J Jaworska… - … of Neuropatholgy & …, 2017 - academic.oup.com
Neonatal hypoxia-ischemia (HI) is one of the major causes of death and/or lifelong
neurobehavioral and cognitive dysfunction. Undoubtedly, brain damage following HI insult is …

Myricetin attenuates hypoxic-ischemic brain damage in neonatal rats via NRF2 signaling pathway

T Chen, Y Hu, L Lu, Q Zhao, X Tao, B Ding… - Frontiers in …, 2023 - frontiersin.org
Introduction: Hypoxic-ischemic encephalopathy (HIE) is a crucial cause of neonatal death
and neurological sequelae, but currently there is no effective therapy drug for HIE. Both …

Exogenous lactate administration: a potential novel therapeutic approach for neonatal hypoxia-ischemia

Q Deng, C Wu, TCY Liu, R Duan, L Yang - Experimental Neurology, 2023 - Elsevier
Neonatal hypoxic-ischemic encephalopathy (HIE) is the primary reason for neonatal
mortality and prolonged disablement. Currently, hypothermia is the only approved clinical …

Lactylation may be a novel posttranslational modification in inflammation in neonatal hypoxic-ischemic encephalopathy

Y Zhou, L Yang, X Liu, H Wang - Frontiers in pharmacology, 2022 - frontiersin.org
Perinatal hypoxia-ischemia remains the most common cause of acute neonatal brain injury
and is associated with a high death rate and long-term neurological abnormalities such as …