Increase in head and neck cancer in younger patients due to human papillomavirus (HPV)

D Young, CC Xiao, B Murphy, M Moore, C Fakhry… - Oral oncology, 2015 - Elsevier
The face of head and neck cancer has changed dramatically over the past 30 years. There
has been a steady decline in the number of tobacco and alcohol related squamous cell …

Extracapsular spread in head and neck squamous cell carcinoma: a systematic review and meta-analysis

M Mermod, G Tolstonog, C Simon, Y Monnier - Oral oncology, 2016 - Elsevier
Extracapsular spread (ECS) is one of the most important prognostic factors in head and neck
squamous cell carcinoma (HNSCC). However, despite its major clinical relevance, there are …

NCCN Guidelines® insights: Head and neck cancers, version 1.2022: Featured updates to the NCCN guidelines

JJ Caudell, ML Gillison, E Maghami, S Spencer… - Journal of the National …, 2022 - jnccn.org
The NCCN Guidelines for Head and Neck Cancers address tumors arising in the oral cavity
(including mucosal lip), pharynx, larynx, and paranasal sinuses. Occult primary cancer …

Head and neck cancers—major changes in the American Joint Committee on cancer eighth edition cancer staging manual

WM Lydiatt, SG Patel, B O'Sullivan… - CA: a cancer journal …, 2017 - Wiley Online Library
Answer questions and earn CME/CNE The recently released eighth edition of the American
Joint Committee on Cancer (AJCC) Staging Manual, Head and Neck Section, introduces …

Influence of extracapsular nodal spread extent on prognosis of oral squamous cell carcinoma

VB Wreesmann, N Katabi, FL Palmer… - Head & …, 2016 - Wiley Online Library
Background An objective definition of clinically relevant extracapsular nodal spread (ECS) in
head and neck squamous cell carcinoma (SCC) is unavailable. Methods Pathologic review …

A systematic review of transoral robotic surgery and radiotherapy for early oropharynx cancer: a systematic review

JR De Almeida, JK Byrd, R Wu, CL Stucken… - The …, 2014 - Wiley Online Library
Objectives/Hypothesis To demonstrate the comparative effectiveness of transoral robotic
surgery (TORS) to intensity modulated radiotherapy (IMRT) for early T‐stage oropharyngeal …

High metastatic node number, not extracapsular spread or N-classification is a node-related prognosticator in transorally-resected, neck-dissected p16-positive …

P Sinha, D Kallogjeri, H Gay, WL Thorstad, JS Lewis Jr… - Oral oncology, 2015 - Elsevier
Background Due to unique biology and prognosis, precise identification of predictive
parameters is critical for p16+ oropharyngeal squamous cell carcinoma (OPSCC). Prior …

A review of the 8th edition of the AJCC staging system for oropharyngeal cancer according to HPV status

P Machczyński, E Majchrzak, P Niewinski… - European Archives of …, 2020 - Springer
Background The incidence of oropharyngeal squamous cell carcinoma (OPSCC) has
increased substantially in recent decades, particularly p16-positive human papillomavirus …

Pathology-based staging for HPV-positive squamous carcinoma of the oropharynx

BH Haughey, P Sinha, D Kallogjeri, RL Goldberg… - Oral oncology, 2016 - Elsevier
Objective The rapid worldwide rise in incidence of human papillomavirus (HPV)-positive
oropharyngeal squamous cell carcinoma (OPSCC) has generated studies confirming this …

Detailed analysis of clinicopathologic factors demonstrate distinct difference in outcome and prognostic factors between surgically treated HPV-positive and negative …

NG Iyer, S Dogan, F Palmer, R Rahmati… - Annals of surgical …, 2015 - Springer
Background Oropharyngeal cancers (OPC) secondary to human papillomavirus (HPV)
infections likely represent a completely different disease compared with conventional head …