The DEAD-box helicase family member DDX3X (DBX, DDX3) functions in nearly all stages
of RNA metabolism and participates in the progression of many diseases, including virus …

The translation of messenger RNAs (mRNAs) into proteins is a key event in the regulation of
gene expression. This is especially true in the cancer setting, as many oncogenes and …

Translational control targeting the initiation phase is central to the regulation of gene
expression. Understanding all of its aspects requires substantial technological …

Oncogenic lesions up-regulate bioenergetically demanding cellular processes, such as
protein synthesis, to drive cancer cell growth and continued proliferation. However, the …

Small nucleolar RNAs (snoRNAs) are a diverse group of non-coding RNAs that direct
chemical modifications at specific residues on other RNA molecules, primarily on ribosomal …

To ensure efficient propagation, viruses need to rapidly produce viral proteins after cell
entrance. Since viral genomes do not encode any components of the protein biosynthesis …

Protein synthesis is mediated via numerous molecules including the ribosome, mRNA,
tRNAs, as well as translation initiation, elongation and release factors. Some of these factors …

Plasticity of neoplasia, whereby cancer cells attain stem-cell-like properties, is required for
disease progression and represents a major therapeutic challenge. We report that in breast …

Cleavage of transfer (t) RNA and ribosomal (r) RNA are critical and conserved steps of
translational control for cells to overcome varied environmental stresses. However, enzymes …

Colorectal cancers (CRCs) are composed of an amalgam of cells with distinct genotypes
and phenotypes. Here, we reveal a previously unappreciated heterogeneity in the …