Hypoxia a hallmark of solid tumors makes hypoxic cells radioresistant. On the other
hand, DNA, the main target of anticancer therapy, is not sensitive to the near UV photons …

Dehalogenation is one of the highly important degradation reactions for halogenated
organic compounds (HOCs) in the environment, which is also being developed as a …

Halogenated nucleobases are used as radiosensitizers in cancer radiation therapy,
enhancing the reactivity of DNA to secondary low‐energy electrons (LEEs). LEEs induce …

The TYT and TXT trimeric oligonucleotides, where X stands for a native nucleobase, T
(thymine), C (cytosine), A (adenine), or G (guanine), and Y indicates a brominated analogue …

Hypoxia, a hallmark of solid tumors, which account for ca. 80% of cancer cases, makes the
cancer cells resistant toward ionizing radiation and as a consequence to radiotherapy, one …

Tumor hypoxia hampers radiotherapy efficacy, necessitating radiosensitizers. Substituted
nucleobases offer advantages as radiosensitizers. They can be incorporated into DNA with …

Abstract Although 5‐bromo‐2′‐deoxyuridine (5BrdU) possesses significant
radiosensitizing power in vitro, clinical studies do not confirm any advantages of …

Previous density functional theory (DFT) studies on 6-brominated pyrimidine nucleosides
suggest that 6-iodo-2′-deoxyuridine (6IdU) should act as a better radiosensitizer than its 5 …

Experimental studies showed that high energy radiation induced base release and DNA
backbone breaks mainly occur at the neighboring 5′ nucleotide when a single-stranded …

Abstract In der Krebs‐Strahlentherapie werden halogenierte Nukleinbasen als
Radiosensibilisatoren eingesetzt, um die Reaktivität der DNA gegenüber …