Cerebral malaria: mechanisms of brain injury and strategies for improved neurocognitive outcome

R Idro, K Marsh, CC John, CRJ Newton - Pediatric research, 2010 - nature.com
Cerebral malaria is the most severe neurological complication of infection with Plasmodium
falciparum. With> 575,000 cases annually, children in sub-Saharan Africa are the most …

Changes in the burden of malaria in sub-Saharan Africa

WP O'Meara, JN Mangeni, R Steketee… - The Lancet infectious …, 2010 - thelancet.com
The burden of malaria in countries in sub-Saharan Africa has declined with scaling up of
prevention, diagnosis, and treatment. To assess the contribution of specific malaria …

Iron fortification adversely affects the gut microbiome, increases pathogen abundance and induces intestinal inflammation in Kenyan infants

T Jaeggi, GAM Kortman, D Moretti, C Chassard… - Gut, 2015 - gut.bmj.com
Background In-home iron fortification for infants in developing countries is recommended for
control of anaemia, but low absorption typically results in> 80% of the iron passing into the …

Four-year efficacy of RTS, S/AS01E and its interaction with malaria exposure

A Olotu, G Fegan, J Wambua… - … England Journal of …, 2013 - Mass Medical Soc
Background The candidate malaria vaccine RTS, S/AS01E has entered phase 3 trials, but
data on long-term outcomes are limited. Methods For 4 years, we followed children who had …

A world malaria map: Plasmodium falciparum endemicity in 2007

SI Hay, CA Guerra, PW Gething, AP Patil… - PLoS …, 2009 - journals.plos.org
Background Efficient allocation of resources to intervene against malaria requires a detailed
understanding of the contemporary spatial distribution of malaria risk. It is exactly 40 y since …

[HTML][HTML] Chronic exposure to Plasmodium falciparum is associated with phenotypic evidence of B and T cell exhaustion

J Illingworth, NS Butler, S Roetynck… - The Journal of …, 2013 - journals.aai.org
Naturally acquired immunity to malaria develops slowly, requiring several years of repeated
exposure to be effective. The cellular and molecular factors underlying this observation are …

Effect of a fall in malaria transmission on morbidity and mortality in Kilifi, Kenya

WP O'Meara, P Bejon, TW Mwangi, EA Okiro, N Peshu… - The lancet, 2008 - thelancet.com
Background As efforts to control malaria are expanded across the world, understanding the
role of transmission intensity in determining the burden of clinical malaria is crucial to the …

The Limits and Intensity of Plasmodium falciparum Transmission: Implications for Malaria Control and Elimination Worldwide

CA Guerra, PW Gikandi, AJ Tatem, AM Noor… - PLoS …, 2008 - journals.plos.org
Background The efficient allocation of financial resources for malaria control using
appropriate combinations of interventions requires accurate information on the geographic …

Relation between falciparum malaria and bacteraemia in Kenyan children: a population-based, case-control study and a longitudinal study

JAG Scott, JA Berkley, I Mwangi, L Ochola, S Uyoga… - The Lancet, 2011 - thelancet.com
Background Many investigators have suggested that malaria infection predisposes
individuals to bacteraemia. We tested this hypothesis with mendelian randomisation studies …

[PDF][PDF] Development of a metabolically active, non-replicating sporozoite vaccine to prevent Plasmodium falciparum malaria

SL Hoffman, PF Billingsley, E James, A Richman… - Human …, 2010 - Taylor & Francis
Pronouncements have been made for more than 25 years that the development and
implementation of a highly effective malaria vaccine is imminent. In the case of pre …