The functional roles of S‐adenosyl‐methionine and S‐adenosyl‐homocysteine and their involvement in trisomy 21

M Caracausi, G Ramacieri, F Catapano, M Cicilloni… - …, 2024 - Wiley Online Library
The one‐carbon metabolism pathway is involved in critical human cellular functions such as
cell proliferation, mitochondrial respiration, and epigenetic regulation. In the homocysteine …

[HTML][HTML] Unlocking the Gateway: The Spatio-Temporal Dynamics of the p53 Family Driven by the Nuclear Pores and Its Implication for the Therapeutic Approach in …

DK Ikliptikawati, K Makiyama, M Hazawa… - International Journal of …, 2024 - mdpi.com
The p53 family remains a captivating focus of an extensive number of current studies.
Accumulating evidence indicates that p53 abnormalities rank among the most prevalent in …

Exploring the brain epitranscriptome: perspectives from the NSAS summit

SM Lee, B Koo, C Carré, A Fischer, C He… - Frontiers in …, 2023 - frontiersin.org
Increasing evidence reinforces the essential function of RNA modifications in development
and diseases, especially in the nervous system. RNA modifications impact various …

Lost in translation: How neurons cope with tRNA decoding

G Wei, S Russo, F Tuorto - BioEssays, 2024 - Wiley Online Library
Post‐transcriptional tRNA modifications contribute to the decoding efficiency of tRNAs by
supporting codon recognition and tRNA stability. Recent work shows that the molecular and …

Targeting epitranscriptomics for novel drug development

S Vemulapalli - Biochemical and Molecular Pharmacology in Drug …, 2024 - Elsevier
Epitranscriptomics is a vital frontier in molecular biology, shedding light on RNA
modifications and their influence on gene expression and cellular functionality, which is …

Functions of the ribose methyltransferase FTSJ1 in regulation of gene expression and neural development

M Brazane - 2023 - theses.hal.science
RNAs of all the domains of life carry chemical modifications. Extensive studies over the last
decades linked the loss of RNA modification enzymes to several pathologies, notably, ones …