Glaucoma is one of the leading causes of vision impairment worldwide. In order to further
understand the molecular pathobiology of this disease and to develop better therapies …

There is substantial evidence that elevated intraocular pressure (IOP) is a critical risk factor
for glaucoma. Even with exhaustive investigation, however, there is still little understanding …

Retinal ganglion cell (RGC) loss is a hallmark of glaucoma and the second leading cause of
blindness worldwide. The type and timing of cellular changes leading to RGC loss in …

purpose. To develop a modified adenoassociated viral (AAV) vector capable of efficient
transfection of retinal ganglion cells (RGCs) and to test the hypothesis that use of this vector …

purpose. To determine the chronology of optic nerve head and retinal responses to elevated
intraocular pressure (IOP). methods. After 1 to 39 days of unilaterally elevated IOP …

Animal models are useful to elucidate the etiology and pathology of glaucoma and to
develop novel and more effective therapies for the disease. Because of the substantial …

Glaucomatous optic neuropathy is the leading cause of irreversible blindness in the world.
The chronic disease is characterized by optic nerve degeneration and vision field loss. The …

purpose. To characterize the effect of intraocular pressure (IOP) on optic disc topography,
retinal function, and axonal survival in a model of IOP-induced optic nerve damage in rat …

Biomechanics is the study of the relationship between forces and function in living
organisms and is thought to play a critical role in a significant number of ophthalmic …

Open angle glaucoma is defined as a progressive and time-dependent death of retinal
ganglion cells concomitant with high intraocular pressure, leading to loss of visual field …