The greatest unmet therapeutic need in Parkinson's disease is the development of treatment
that slows the relentless progression of the neurodegenerative process. The concept of …

Parkinson's disease is the second most common neurodegenerative disorder. Although the
pathogenesis of Parkinson's disease is not entirely clear, the aberrant aggregation of α …

Altered degradation of α-synuclein (α-syn) has been implicated in the pathogenesis of
Parkinson disease (PD). We have shown that α-syn can be degraded via chaperone …

Parkinson's disease (PD) is a progressive neurodegenerative disorder that is characterized
by a loss of dopaminergic neurons, leading to bradykinesia, rigidity, tremor at rest, and …

Aggregation of α‐synuclein, an abundant and conserved pre‐synaptic brain protein, is
implicated as a critical factor in several neurodegenerative diseases. These diseases …

Sulfhydryl chemistry plays a vital role in normal biology and in defense of cells against
oxidants, free radicals, and electrophiles. Modification of critical cysteine residues is an …

Background The mechanisms through which aberrant α-synuclein (ASYN) leads to neuronal
death in Parkinson's disease (PD) are uncertain. In isolated liver lysosomes, mutant ASYNs …

Background: Recent studies have demonstrated an association between a Mediterranean‐
type diet and Alzheimer's risk. We assessed the association between Mediterranean‐type …

Background: Several studies have shown associations between Parkinson Disease (PD)
risk and individual foods and nutrients with inconsistent results. Objective: We examined …

Parkinson's disease (PD) is a neurodegenerative disorder etiologically linked to the loss of
substantia nigra (SN) dopaminergic neurons in the mid-brain. The etiopathology of sporadic …