Chronic myeloid leukemia (CML) has been a “model disease” with a long history. Beginning
with the first discovery of leukemia and the description of the Philadelphia Chromosome and …

Soon after the discovery of the Myc gene (c-Myc), it became clear that Myc expression levels
tightly correlate to cell proliferation. The entry in cell cycle of quiescent cells upon Myc …

Neuroblastoma, the most common extracranial solid tumor of childhood, is thought to
originate from undifferentiated neural crest cells. Amplification of the MYC family member …

Chronic myeloid leukaemia (CML) arises after transformation of a haemopoietic stem cell
(HSC) by the protein-tyrosine kinase BCR–ABL. Direct inhibition of BCR–ABL kinase has …

NUT midline carcinoma (NMC) is an aggressive type of squamous cell carcinoma that is
defined by the presence of BRD-NUT fusion oncogenes, which encode chimeric proteins …

Philadelphia (Ph*)/BCR-ABL1-positive chronic myeloid leukemia (CML) is a neoplastic
hematologic disorder, which is a functionally curable chronic disease via using tyrosine …

Nowadays, drug resistance still represents a major obstacle to successful acute myeloid
leukemia (AML) treatment and the underlying mechanism is not fully elucidated. Here, we …

Tumor progression to invasive carcinoma is associated with activation of SRC family kinase
(SRC, YES, FYN) activity and loss of cellular cohesion. The hippo pathway-regulated …

Motivation Interactions among cis-regulatory elements such as enhancers and promoters
are main driving forces shaping context-specific chromatin structure and gene expression …

Identifying and therapeutically targeting cancer cell liabilities is of utmost importance in order
to improve the treatment of patients with malignancies of poor prognosis. The MYC family …