A guide to assessing cellular senescence in vitro and in vivo

E González‐Gualda, AG Baker, L Fruk… - The FEBS …, 2021 - Wiley Online Library
Cellular senescence is a physiological mechanism whereby a proliferating cell undergoes a
stable cell cycle arrest upon damage or stress and elicits a secretory phenotype. This highly …

Cellular senescence in cancer: from mechanisms to detection

HL Ou, R Hoffmann, C González‐López… - Molecular …, 2021 - Wiley Online Library
Senescence refers to a cellular state featuring a stable cell‐cycle arrest triggered in
response to stress. This response also involves other distinct morphological and intracellular …

A synergistic strategy to develop photostable and bright dyes with long Stokes shift for nanoscopy

G Jiang, TB Ren, E D'Este, M Xiong, B Xiong… - Nature …, 2022 - nature.com
The quality and application of super-resolution fluorescence imaging greatly lie in the dyes'
properties, including photostability, brightness, and Stokes shift. Here we report a synergistic …

Self-immolative colorimetric, fluorescent and chemiluminescent chemosensors

J Yan, S Lee, A Zhang, J Yoon - Chemical Society Reviews, 2018 - pubs.rsc.org
Self-immolative chemistry features a cascade of disassembly reactions in response to
external stimuli, which provides great opportunities to design new self-immolative …

Osteoclasts protect bone blood vessels against senescence through the angiogenin/plexin-B2 axis

X Liu, Y Chai, G Liu, W Su, Q Guo, X Lv, P Gao… - Nature …, 2021 - nature.com
Synthetic glucocorticoids (GCs), one of the most effective treatments for chronic inflammatory
and autoimmune conditions in children, have adverse effects on the growing skeleton. GCs …

Chemosensor with ultra-high fluorescence enhancement for assisting in diagnosis and resection of ovarian cancer

L Xu, H Chu, D Gao, Q Wu, Y Sun, Z Wang… - Analytical …, 2023 - ACS Publications
Fluorescence imaging-guided diagnostics is one of the most promising approaches for facile
detection of tumors in situ owing to its simple operation and non-invasiveness. As a crucial …

An enzyme-activatable probe liberating AIEgens: on-site sensing and long-term tracking of β-galactosidase in ovarian cancer cells

K Gu, W Qiu, Z Guo, C Yan, S Zhu, D Yao, P Shi… - Chemical …, 2019 - pubs.rsc.org
Development of fluorescent probes for on-site sensing and long-term tracking of specific
biomarkers is particularly desirable for the early detection of diseases. However, available …

γ‐Glutamyltranspeptidase (GGT)‐activatable fluorescence probe for durable tumor imaging

R Obara, M Kamiya, Y Tanaka, A Abe… - Angewandte Chemie …, 2021 - Wiley Online Library
Abstract γ‐Glutamyltranspeptidase (GGT) is overexpressed in several types of cancer.
Existing GGT‐targeting fluorescence probes can image these cancers, but the fluorescent …

Xanthene dyes for cancer imaging and treatment: A material odyssey

O Karaman, GA Alkan, C Kizilenis, CC Akgul… - Coordination Chemistry …, 2023 - Elsevier
Cancer is still among the leading health issues today, considering the cost, effectiveness,
complexity of detection/treatment modalities and survival rates. One of the most important …

A tandem activity-based sensing and labeling strategy enables imaging of transcellular hydrogen peroxide signaling

H Iwashita, E Castillo, MS Messina… - Proceedings of the …, 2021 - National Acad Sciences
Reactive oxygen species (ROS) like hydrogen peroxide (H2O2) are transient species that
have broad actions in signaling and stress, but spatioanatomical understanding of their …