A theory that predicts behaviors of disordered cytoskeletal networks

JM Belmonte, M Leptin, F Nédélec - Molecular systems biology, 2017 - embopress.org
Morphogenesis in animal tissues is largely driven by actomyosin networks, through tensions
generated by an active contractile process. Although the network components and their …

Hierarchical biomechanics: concepts, bone as prominent example, and perspectives beyond

C Hellmich, N Ukaj, B Smeets… - Applied …, 2022 - asmedigitalcollection.asme.org
The main motivation for “hierarchical biomechanics” is that the wide variability of mechanical
properties encountered at the macroscopic scale may be traced back to just a few …

Classical and emerging regulatory mechanisms of cytokinesis in animal cells

V Verma, A Mogilner, TJ Maresca - Biology, 2019 - mdpi.com
The primary goal of cytokinesis is to produce two daughter cells, each having a full set of
chromosomes. To achieve this, cells assemble a dynamic structure between segregated …

Filament-guided filament assembly provides structural memory of filament alignment during cytokinesis

Y Li, E Munro - Developmental cell, 2021 - cell.com
During cytokinesis, animal cells rapidly remodel the equatorial cortex to build an aligned
array of actin filaments called the contractile ring. Local reorientation of filaments by active …

Modeling cell migration regulated by cell extracellular-matrix micromechanical coupling

Y Zheng, H Nan, Y Liu, Q Fan, X Wang, R Liu, L Liu… - Physical Review E, 2019 - APS
Cell migration in fibrous extracellular matrix (ECM) is crucial to many physiological and
pathological processes such as tissue regeneration, immune response, and cancer …

[HTML][HTML] Plastin and spectrin cooperate to stabilize the actomyosin cortex during cytokinesis

AF Sobral, FY Chan, MJ Norman, DS Osório, AB Dias… - Current Biology, 2021 - cell.com
Cytokinesis, the process that partitions the mother cell into two daughter cells, requires the
assembly and constriction of an equatorial actomyosin network. Different types of non-motor …

Nonequilibrium phase diagrams for actomyosin networks

SL Freedman, GM Hocky, S Banerjee, AR Dinner - Soft matter, 2018 - pubs.rsc.org
Living cells dynamically modulate the local morphologies of their actin networks to perform
biological functions, including force transduction, intracellular transport, and cell division. A …

Remarkable structural transformations of actin bundles are driven by their initial polarity, motor activity, crosslinking, and filament treadmilling

A Chandrasekaran, A Upadhyaya… - PLoS computational …, 2019 - journals.plos.org
Bundled actin structures play a key role in maintaining cellular shape, in aiding force
transmission to and from extracellular substrates, and in affecting cellular motility. Recent …

Coarse-grained dynamics of transiently bound fast linkers

S Marbach, CE Miles - The Journal of Chemical Physics, 2023 - pubs.aip.org
Transient bonds between fast linkers and slower particles are widespread in physical and
biological systems. Despite their diverse structure and function, a commonality is that the …

Cross-linkers both drive and brake cytoskeletal remodeling and furrowing in cytokinesis

CP Descovich, DB Cortes, S Ryan, J Nash… - Molecular Biology of …, 2018 - Am Soc Cell Biol
Cell shape changes such as cytokinesis are driven by the actomyosin contractile
cytoskeleton. The molecular rearrangements that bring about contractility in nonmuscle cells …