The diverse functions of GAPDH: views from different subcellular compartments

C Tristan, N Shahani, TW Sedlak, A Sawa - Cellular signalling, 2011 - Elsevier
Multiple roles for glyceraldehyde-3-phosphate dehydrogenase (GAPDH) have been recently
appreciated. In addition to the cytoplasm where the majority of GAPDH is located under the …

Phospholipase D signaling pathways and phosphatidic acid as therapeutic targets in cancer

RC Bruntz, CW Lindsley, HA Brown, DR Sibley - Pharmacological reviews, 2014 - Elsevier
Phospholipase D is a ubiquitous class of enzymes that generates phosphatidic acid as an
intracellular signaling species. The phospholipase D superfamily plays a central role in a …

[HTML][HTML] Protein oxidation and cellular homeostasis: Emphasis on metabolism

V Cecarini, J Gee, E Fioretti, M Amici… - … et Biophysica Acta (BBA …, 2007 - Elsevier
Reactive oxygen species (ROS) are generated as the result of a number of physiological
and pathological processes. Once formed ROS can promote multiple forms of oxidative …

AtPDR12 contributes to lead resistance in Arabidopsis

M Lee, K Lee, J Lee, EW Noh, Y Lee - Plant physiology, 2005 - academic.oup.com
Arabidopsis (Arabidopsis thaliana) contains about 130 ATP-binding cassette (ABC) proteins,
which are likely to contribute to the transport of diverse materials, including toxic substances …

Understanding the role of H2O2 during pea seed germination: a combined proteomic and hormone profiling approach

G BARBA‐ESPÍN, P DIAZ‐VIVANCOS… - Plant, Cell & …, 2011 - Wiley Online Library
In a previous publication, we showed that the treatment of pea seeds in the presence of
hydrogen peroxide (H2O2) increased germination performance as well as seedling growth …

Proteomic identification of glyceraldehyde 3-phosphate dehydrogenase as an inhibitory target of hydrogen peroxide in Arabidopsis

JT Hancock, D Henson, M Nyirenda, R Desikan… - Plant Physiology and …, 2005 - Elsevier
Hydrogen peroxide (H2O2) is now recognised as a key signalling molecule in eukaryotes. In
plants, H2O2 is involved in regulating stomatal closure, gravitropic responses, gene …

The writers, readers, and erasers in redox regulation of GAPDH

MA Tossounian, B Zhang, I Gout - Antioxidants, 2020 - mdpi.com
Glyceraldehyde 3–phosphate dehydrogenase (GAPDH) is a key glycolytic enzyme, which is
crucial for the breakdown of glucose to provide cellular energy. Over the past decade …

Doing the unexpected: proteins involved in hydrogen peroxide perception

J Hancock, R Desikan, J Harrison… - Journal of …, 2006 - academic.oup.com
A look back at the early literature on reactive oxygen species (ROS) gives the impression
that these small inorganic molecules had a singular defined role, that of host defence in …

Structural analysis of glyceraldehyde-3-phosphate dehydrogenase functional diversity

MA Sirover - The international journal of biochemistry & cell biology, 2014 - Elsevier
Multifunctional proteins provide a new mechanism to expand exponentially cell information
and capability beyond that indicated by conventional gene analyses. As such, examination …

Metabolite itaconate in host immunoregulation and defense

W Yang, Y Wang, K Tao, R Li - Cellular & Molecular Biology Letters, 2023 - Springer
Metabolic states greatly influence functioning and differentiation of immune cells. Regulating
the metabolism of immune cells can effectively modulate the host immune response …