Antibodies and antibody-derived macromolecules have established themselves as the
mainstay in protein-based therapeutic molecules (biologics). Our knowledge of the structure …

Anatomy of the antibody molecule - ScienceDirect Skip to main contentSkip to article Elsevier
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RANDOM association of VL and VH repertoires contributes considerably to antibody
diversity1. The diversity and the affinity are then increased by hypermutation in B cells …

The variable domains of an antibody consist of a β-sheet framework with hypervariable
regions (or complementarity-determining regions—CDRs) which fashion the antigen …

Single-chain antigen-binding proteins are novel recombinant polypeptides, composed of an
antibody variable light-chain amino acid sequence (VL) tethered to a variable heavy-chain …

This volume of" Water-A Comprehensive Treatise" is devoted to aqueous solutions of
macromolecules and aqueous systems of small molecules which exhibit reversible …

A simple diagrammatic representation has been used to show the arrangement of α helices
and β sheets in 31 globular proteins, which are classified into four clearly separated classes …

The catalytic sites of influenza virus neuraminidase are located on the upper corners of the
box-shaped tetramer that forms the head of the molecule. Antigenic determinants form a …

Rodent monoclonal antibodies have been “humanized” or “reshaped” for therapy by
transplanting the antigen-binding loops from their variable domains onto the β-sheet …

Publisher Summary The chapter discusses the structural analysis of amyloid fibrils by
electron microscopy and X-ray diffraction. A method to isolate amyloid fibrils from tissue was …