Although aminoglycosides have been used as antibacterials for decades, their use has
been hindered by their inherent toxicity and the resistance that has emerged to these …

Enzymatic modification is a prevalent mechanism by which bacteria defeat the action of
antibiotics. Aminoglycosides are often inactivated by aminoglycoside modifying enzymes …

The key role of the bacterial ribosome makes it an important target for antibacterial agents.
Indeed, a large number of clinically useful antibiotics target this complex translational …

Nonsense mutations promote premature translational termination and represent the
underlying cause of a large number of human genetic diseases. The aminoglycoside …

The structural and regulatory elements in therapeutically relevant RNAs offer many
opportunities for targeting by small molecules, yet fundamental understanding of what drives …

Nonsense mutations, generating premature termination codons (PTCs), account for 10% to
30% of the mutations in tumor suppressor genes. Nonsense translational suppression …

New pseudo-di-and pseudo-trisaccharide derivatives of the aminoglycoside drug G418
were designed, synthesized and their ability to readthrough nonsense mutations was …

There is compelling evidence that aminoglycoside (AG) antibiotics can induce the
mammalian ribosome to suppress disease-causing nonsense mutations and partially …

Leishmania is a single-celled eukaryotic parasite afflicting millions of humans worldwide,
with current therapies limited to a poor selection of drugs that mostly target elements in the …

A systematic analysis of all synthetic and chemoenzymatic methodologies for the
preparation of aminoglycosides for a variety of applications (therapeutic and agricultural) …