Introduction: 15-Lipoxygenases (15-LOXes) are a family of iron-containing proteins that
have the capability for unsaturated fatty acid peroxidation in animals and plants. Two types …

The targeted degradation of histone deacetylase 6 (HDAC6) by heterobifunctional
degraders constitutes a promising approach to treat HDAC6-driven diseases. Previous …

Oleic acid and its phospholipid derivatives are fundamental to the structure and function of
cellular membranes. As a result, there has been increasing interest in the availability of their …

Background: Increased death due to the opioid epidemic in the United States has
necessitated the development of new strategies to treat addiction. Monoclonal antibodies …

Due to sedentary lifestyle and harsh environmental conditions, gorgonian coral extracts are
recognized as a rich source of novel compounds with various biological activities, of interest …

The first total syntheses of four stereoisomers of 13‐hydroxy‐14‐methylhexadecanoic acid
have been accomplished. Central to this strategy are asymmetric alkynylation of aldehyde …

Lipoxygenases (LOs) include several members and constitute a family of dioxygenases
containing one nonheme iron atom per molecule, which oscillates between Fe2+ (inactive …

De précédentes études dans notre groupe ont montré que l'α-1-C-nonyl-1, 5-didésoxy-1, 5-
imino-D-xylitol était un inhibiteur puissant de la β-glucocérébrosidase, enzyme impliquée …

Soybean lipoxygenases (soybean lipoxygenase-1) has been a well-studied enzyme
because it is considered as a model enzyme for mammalian lipoxygenases. In general, the …

The study of proteins associated with epigenetics is an ever expanding field of study. Lysine
Specific Demethylase 1A (LSD1), existing within the co-repressor to the transcription factor …