The role of peroxisome proliferator-activated receptors in carcinogenesis and chemoprevention
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription
factors that are involved in regulating glucose and lipid homeostasis, inflammation …
factors that are involved in regulating glucose and lipid homeostasis, inflammation …
Apoptosis-inducing effects of amaryllidaceae alkaloids
J J. Nair, J van Staden, J Bastida - Current medicinal chemistry, 2016 - benthamdirect.com
The Amaryllidaceae occupies a privileged status amongst medicinal plants in having
delivered the Alzheimer's drug galanthamine to the clinical market. Following its resounding …
delivered the Alzheimer's drug galanthamine to the clinical market. Following its resounding …
Drug redeployment to kill leukemia and lymphoma cells by disrupting SCD1-mediated synthesis of monounsaturated fatty acids
The redeployed drug combination of bezafibrate and medroxyprogesterone acetate
(designated BaP) has potent in vivo anticancer activity in acute myelogenous leukemia …
(designated BaP) has potent in vivo anticancer activity in acute myelogenous leukemia …
Comprehensive lipidomics analysis of bioactive lipids in complex regulatory networks
In the present work we describe the development of an analytical technique for
simultaneous profiling of over 100 biochemically related lipid mediators in biological …
simultaneous profiling of over 100 biochemically related lipid mediators in biological …
Combined bezafibrate and medroxyprogesterone acetate: potential novel therapy for acute myeloid leukaemia
Background The majority of acute myeloid leukaemia (AML) patients are over sixty years of
age. With current treatment regimens, survival rates amongst these, and also those younger …
age. With current treatment regimens, survival rates amongst these, and also those younger …
[HTML][HTML] Acute and chronic saturated fatty acid treatment as a key instigator of the TLR-mediated inflammatory response in human adipose tissue, in vitro
EM Youssef-Elabd, KC McGee, G Tripathi… - The Journal of nutritional …, 2012 - Elsevier
A post-prandial increase in saturated fatty acids (SFAs) and glucose (Glc) activates an
inflammatory response, which may be prolonged following restoration of physiological SFAs …
inflammatory response, which may be prolonged following restoration of physiological SFAs …
Lack of functional and expression homology between human and mouse aldo-keto reductase 1C enzymes: implications for modelling human cancers
Background Over recent years, enzymes of the aldo-keto reductase (AKR) 1C subfamily
have been implicated in the progression of prostate, breast, endometrial and leukemic …
have been implicated in the progression of prostate, breast, endometrial and leukemic …
Aldo-keto reductase 1C3 (AKR1C3): a missing piece of the puzzle in the dinaciclib interaction profile
E Novotná, N Büküm, J Hofman, M Flaxová… - Archives of …, 2018 - Springer
Dinaciclib is a multi-specific cyclin-dependent kinase (CDK) inhibitor with significant
preclinical and clinical activity. It inhibits CDK1, CDK2, CDK5, CDK9 and CDK12 in the …
preclinical and clinical activity. It inhibits CDK1, CDK2, CDK5, CDK9 and CDK12 in the …
Repair of oxidative DNA damage is delayed in the Ser326Cys polymorphic variant of the base excision repair protein OGG1
RM Kershaw, NJ Hodges - Mutagenesis, 2012 - academic.oup.com
Gene–environment interactions influence an individual's risk of disease development. A
common human 8-oxoguanine DNA glycosylase 1 (OGG1) variant, Cys326-hOGG1, has …
common human 8-oxoguanine DNA glycosylase 1 (OGG1) variant, Cys326-hOGG1, has …
Retinaldehyde is a substrate for human aldo–keto reductases of the 1C subfamily
FX Ruiz, S Porté, O Gallego, A Moro… - Biochemical …, 2011 - portlandpress.com
Human AKR (aldo–keto reductase) 1C proteins (AKR1C1–AKR1C4) exhibit relevant activity
with steroids, regulating hormone signalling at the pre-receptor level. In the present study …
with steroids, regulating hormone signalling at the pre-receptor level. In the present study …