Glycogen is a branched polymer of glucose that acts as a store of energy in times of
nutritional sufficiency for utilization in times of need. Its metabolism has been the subject of …

Starch is the most widespread and abundant storage carbohydrate in plants. We depend
upon starch for our nutrition, exploit its unique properties in industry, and use it as a …

Most neurodegenerative diseases that afflict humans are associated with the
intracytoplasmic deposition of aggregate-prone proteins in neurons. Autophagy is a …

There are many misconceptions surrounding the roles of protein phosphatases in the
regulation of signal transduction, perhaps the most damaging of which is the erroneous view …

Glycosylation defects are a hallmark of many nervous system diseases. However, the
molecular and metabolic basis for this pathology is not fully understood. In this study, we …

Glycogen, the primary storage form of glucose, is a rapid and accessible form of energy that
can be supplied to tissues on demand. Each glycogen granule, or" glycosome," is …

Lafora disease is a severe, autosomal recessive, progressive myoclonus epilepsy. The
disease usually manifests in previously healthy adolescents, and death commonly occurs …

Lafora disease (LD) is an autosomal recessive progressive myoclonus epilepsy due to
mutations in the EPM2A (laforin) and EPM2B (malin) genes, with no substantial genotype …

Protein phosphorylation appears to be a universal mechanism of protein regulation.
Genomics has provided the means to compile inventories of protein phosphatases across a …

Autophagy is an essential cellular process involving degradation of superfluous or defective
macromolecules and organelles as a form of homeostatic recycling. Initially proposed to be …