Hemophilia A and B predominantly attracts clinical attention in males due to X‐linked
inheritance, introducing a bias toward female carriers to be asymptomatic. This common …

Hemophilia A is characterized by deficiency in factor VIII clotting activity that results in
prolonged oozing after injuries, tooth extractions, or surgery, and delayed or recurrent …

Women with bleeding disorders suffer from multiple bleeding symptoms, including easy
bruising, epistaxis, bleeding from minor wounds and the oral cavity, and bleeding after …

Severe and moderate factor VIII (FVIII) or IX (FIX) deficiencies in female carriers of
haemophilia are rarely observed, but mild deficiency is quite frequent, although insufficiently …

Introduction The inherited bleeding disorders (IBD) community has witnessed significant
therapeutic advances recently, yet important gaps persist, particularly for those with rare …

Introduction Certain haemophilia carriers demonstrate an increased bleeding tendency,
mainly related to clotting factor deficiency. No study has so far formally compared the …

Factor VIII (FVIII) circulates in a noncovalent complex with von Willebrand Factor (VWF), the
latter determining FVIII half-life. The VWF-binding aptamer rondaptivon pegol (BT200) …

Prevalence and bleeding tendency of hemophilia A carriers remain underreported, despite a
significant proportion having low FVIII levels. Skewed XCI may explain low FVIII but does not …

Increased von Willebrand factor (VWF) clearance plays a key role in the pathogenesis of
type 1 and type 2 von Willebrand disease (VWD). However, the pathological mechanisms …

Viscoelastic hemostatic assays are point-of-care devices that assess coagulation and
fibrinolysis in whole blood samples. These technologies provide numeric and visual …