Platelets are small anucleated blood cells primarily known for their vital hemostatic role.
Allogeneic platelet concentrates (PCs) collected from healthy donors are an essential …

Articular cartilage is composed of chondrons within a territorial matrix surrounded by a
highly organized extracellular matrix comprising collagen II fibrils, proteoglycans …

Primary articular cartilage-derived cells are among the preferred contenders for cell-based
therapy approaches for cartilage repair. Limited access to primary human cartilage tissue …

A pathogen-free and standardized xeno-free supplement of growth media is required for the
ex vivo propagation of human cells used as advanced therapeutic medicinal products and …

Osteoarthritis (OA) is a degenerative joint disease that affects a lot of people worldwide.
Current treatment for OA mainly focuses on halting or slowing down the disease progress …

It is a great challenge to cure symptomatic lesions and considerable defects of hyaline
cartilage due to its complex structure and poor self-repair capacity. If left untreated …

Platelet lysate (PL) contains a cocktail of growth factors that actively participates in cartilage
repair. This study was designed to determine the effect and mechanism of PL on …

Osteoarthritis (OA) in articular joints is a prevalent disease. With increasing life expectancy,
the need for therapies other than knee replacement arises. The intrinsic repair capacity of …

Cultured autologous human articular chondrocyte (HAC) implantation has been extensively
investigated for safe and effective promotion of structural and functional restoration of knee …

Macrophage-based co-cultures are used to test the immunomodulatory function of candidate
cells for clinical use. This study aimed to characterize a macrophage polarization model …