1, 1-Dihalo-1-alkenes are valuable synthetic tools in organic chemistry and serve as
interesting synthetic intermediates in a variety of non-metal-assisted chemical …

Abstract Combretastatin A-4 (CA-4) is a natural anti-cancer agent isolated in 1989 from the
African willow tree, Combretum caffrum. Due to its chemical simplicity, this (Z)-stilbene has …

Aim: A series of novel trifluoromethylquinoline derivatives were designed, synthesized and
evaluated for antitumor activities. Methodology: All compounds were evaluated for …

Abstract A series of 3-(3′-hydroxy-4′-methoxyphenyl) selenyl-5, 6, 7-trimethoxy-1 H-
indoles and 3-(3′-hydroxy-4′-methoxyphenyl) thio-5, 6, 7-trimethoxy-1 H-indoles were …

Abstract Neuropilin-1 (NRP-1), a transmembrane glycoprotein acting as a co-receptor of
VEGF-A, is expressed by cancer and angiogenic endothelial cells and is involved in the …

One-pot Julia olefination using ribofuranosyl sulfones is described. The α-anomers of the
ribofuranosyl sulfones were synthesized with complete α-selectivity via the glycosylation of …

The Trimethoxyphenyl (TMP) group serves as a pharmacophore in numerous potent agents
exhibiting diverse bioactivity effects. This moiety is prominently present in the molecular …

Colchicine site ligands have proved to be potent inhibitors of tubulin polymerization, which
leads them not only to display cytotoxic effects but also vascular disrupting effects on tumour …

This study reports a new methodology to synthesize exo‐glycals bearing both a sulfone and
a phosphonate. This synthetic strategy provides a way to generate exo‐glycals displaying …

A multiarm nanomedicine template has been designed following bottom-up approach, which
target neuropilin-1 (Nrp-1) receptor of cancer cells. Through this venture, we discovered that …