The challenge of efflux-mediated antibiotic resistance in Gram-negative bacteria
The global emergence of multidrug-resistant Gram-negative bacteria is a growing threat to
antibiotic therapy. The chromosomally encoded drug efflux mechanisms that are ubiquitous …
antibiotic therapy. The chromosomally encoded drug efflux mechanisms that are ubiquitous …
Transposon insertion sequencing: a new tool for systems-level analysis of microorganisms
T Van Opijnen, A Camilli - Nature Reviews Microbiology, 2013 - nature.com
Our knowledge of gene function has increasingly lagged behind gene discovery, hindering
our understanding of the genetic basis of microbial phenotypes. Recently, however …
our understanding of the genetic basis of microbial phenotypes. Recently, however …
Genome-wide identification of Acinetobacter baumannii genes necessary for persistence in the lung
Acinetobacter baumannii is a Gram-negative bacterium that causes diseases such as
pneumonia, bacteremia, and soft tissue infections in hospitalized patients. Relatively little is …
pneumonia, bacteremia, and soft tissue infections in hospitalized patients. Relatively little is …
Robust bioengineered 3D functional human intestinal epithelium
Intestinal functions are central to human physiology, health and disease. Options to study
these functions with direct relevance to the human condition remain severely limited when …
these functions with direct relevance to the human condition remain severely limited when …
The Serum Resistome of a Globally Disseminated Multidrug Resistant Uropathogenic Escherichia coli Clone
Escherichia coli ST131 is a globally disseminated, multidrug resistant clone responsible for
a high proportion of urinary tract and bloodstream infections. The rapid emergence and …
a high proportion of urinary tract and bloodstream infections. The rapid emergence and …
Defining heterogeneity within bacterial populations via single cell approaches
Bacterial populations are heterogeneous, which in many cases can provide a selective
advantage during changes in environmental conditions. In some instances, heterogeneity …
advantage during changes in environmental conditions. In some instances, heterogeneity …
Genome-Wide Detection of Fitness Genes in Uropathogenic Escherichia coli during Systemic Infection
S Subashchandrabose, SN Smith, RR Spurbeck… - PLoS …, 2013 - journals.plos.org
Uropathogenic Escherichia coli (UPEC) is a leading etiological agent of bacteremia in
humans. Virulence mechanisms of UPEC in the context of urinary tract infections have been …
humans. Virulence mechanisms of UPEC in the context of urinary tract infections have been …
Community behavior and spatial regulation within a bacterial microcolony in deep tissue sites serves to protect against host attack
Bacterial pathogens express virulence-specific transcriptional programs that allow tissue
colonization. Although phenotypic variation has been noted in the context of antibiotic …
colonization. Although phenotypic variation has been noted in the context of antibiotic …
Genome-wide transposon mutagenesis of Proteus mirabilis: Essential genes, fitness factors for catheter-associated urinary tract infection, and the impact of …
CE Armbruster, V Forsyth-DeOrnellas… - PLoS …, 2017 - journals.plos.org
The Gram-negative bacterium Proteus mirabilis is a leading cause of catheter-associated
urinary tract infections (CAUTIs), which are often polymicrobial. Numerous prior studies have …
urinary tract infections (CAUTIs), which are often polymicrobial. Numerous prior studies have …
Roles of Efflux Pumps from Different Superfamilies in the Surface-Associated Motility and Virulence of Acinetobacter baumannii ATCC 17978
M Pérez-Varela, J Corral, J Aranda… - Antimicrobial Agents …, 2019 - Am Soc Microbiol
Although the relationship between Acinetobacter baumannii efflux pumps and antimicrobial
resistance is well documented, less is known about the involvement of these proteins in the …
resistance is well documented, less is known about the involvement of these proteins in the …