The ability to preserve genomic integrity is a fundamental feature of life. Recent findings
regarding the molecular basis of the cell-cycle checkpoint responses of mammalian cells to …

Several newly identified tumor suppressor genes including ATM, NBS1, BRCA1 and BRCA2
are involved in DNA double-strand break repair (DSBR) and DNA damage-induced …

Damage induced in the DNA after exposure of cells to ionizing radiation activates
checkpoint pathways that inhibit progression of cells through the G1 and G2 phases and …

The initiation of eukaryotic DNA replication is regulated by three protein kinase classes:
cyclin-dependent kinases (CDK), Dbf4-dependent kinase (DDK) and the DNA damage …

To preserve genetic integrity, mammalian cells exposed to ionizing radiation activate the
ATM kinase, which initiates a complex response—including the S-phase checkpoint …

▪ Abstract The initiation of DNA replication in eukaryotic cells is tightly controlled to ensure
that the genome is faithfully duplicated once each cell cycle. Genetic and biochemical …

Mammalian DNA replication is an elegantly choreographed process in which multiple
components are assembled at the origins to form the prereplication complex. Formation and …

Many replication proteins assemble on the pre-RC-formed replication origins and constitute
the pre-initiation complex (pre-IC). This complex formation facilitates the conversion of Mcm2 …

DNA replication in eukaryotic cells initiates from multiple replication origins that are
distributed throughout the genome. Coordinating the usage of these origins is crucial to …

Eukaryotic cells respond to DNA damage within the S phase by activating an intra-S
checkpoint: a response that includes reducing the rate of DNA synthesis. In yeast cells this …