Signaling pathways in rheumatoid arthritis: implications for targeted therapy

Q Ding, W Hu, R Wang, Q Yang, M Zhu, M Li… - Signal transduction and …, 2023 - nature.com
Rheumatoid arthritis (RA) is an incurable systemic autoimmune disease. Disease
progression leads to joint deformity and associated loss of function, which significantly …

Restoring synovial homeostasis in rheumatoid arthritis by targeting fibroblast-like synoviocytes

G Nygaard, GS Firestein - Nature Reviews Rheumatology, 2020 - nature.com
Rheumatoid arthritis (RA) is a chronic immune-mediated disease that primarily affects the
synovium of diarthrodial joints. During the course of RA, the synovium transforms into a …

Persistent inflammatory and non-inflammatory mechanisms in refractory rheumatoid arthritis

MH Buch, S Eyre, D McGonagle - Nature Reviews Rheumatology, 2021 - nature.com
Despite nearly three decades of advances in the management of rheumatoid arthritis (RA), a
substantial minority of patients are exposed to multiple DMARDs without necessarily …

Immunopathogenesis of rheumatoid arthritis

GS Firestein, IB McInnes - Immunity, 2017 - cell.com
Rheumatoid arthritis (RA) is the most common inflammatory arthropathy. The majority of
evidence, derived from genetics, tissue analyses, models, and clinical studies, points to an …

[HTML][HTML] Therapeutic potential of mesenchymal cell–derived miRNA-150-5p–expressing exosomes in rheumatoid arthritis mediated by the modulation of MMP14 and …

Z Chen, H Wang, Y Xia, F Yan, Y Lu - The Journal of Immunology, 2018 - journals.aai.org
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial tissue
inflammation and joint destruction associated with the activation of angiogenesis …

Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors

N Bottini, GS Firestein - Nature Reviews Rheumatology, 2013 - nature.com
Rheumatoid arthritis (RA) is characterized by hyperplastic synovial pannus tissue, which
mediates destruction of cartilage and bone. Fibroblast-like synoviocytes (FLS) are a key …

MicroRNAs in rheumatoid arthritis: From pathogenesis to clinical impact

G Evangelatos, GE Fragoulis, V Koulouri… - Autoimmunity reviews, 2019 - Elsevier
Over the last decade, many epigenetic mechanisms that contribute in the pathogenesis of
autoimmune disorders have been revealed. MicroRNAs (miRNAs) are small, non-coding …

Critical role of synovial tissue–resident macrophage and fibroblast subsets in the persistence of joint inflammation

S Kemble, AP Croft - Frontiers in immunology, 2021 - frontiersin.org
Rheumatoid arthritis (RA) is a chronic prototypic immune-mediated inflammatory disease
which is characterized by persistent synovial inflammation, leading to progressive joint …

MicroRNA epigenetic signatures in human disease

K Piletič, T Kunej - Archives of toxicology, 2016 - Springer
MicroRNAs (miRNAs) are short non-coding RNAs that act as important regulators of gene
expression as part of the epigenetic machinery. In addition to posttranscriptional gene …

MicroRNA-mediated epigenetic regulation of rheumatoid arthritis susceptibility and pathogenesis

C Chang, L Xu, R Zhang, Y Jin, P Jiang, K Wei… - Frontiers in …, 2022 - frontiersin.org
MicroRNAs (miRNAs) play crucial roles in regulating the transcriptome and development of
rheumatoid arthritis (RA). Currently, a comprehensive map illustrating how miRNAs regulate …