Sarcopenia is a loss of muscle protein mass and loss of muscle function. It occurs with
increasing age, being a major component in the development of frailty. Current knowledge …

The treatment of inflammatory bowel disease (IBD) has been revolutionised over the past
decade by the increasing use of immunomodulators, mainly azathioprine (AZA)/6 …

Aim To update recommendations based on current best evidence concerning the treatment
of rheumatoid arthritis (RA), focusing particularly on the role of targeted therapies, to inform …

Background Biological therapy is currently widely used to treat IBD. Infliximab, adalimumab
and golimumab are currently licensed anti‐TNF therapies. Biosimilar anti‐TNF monoclonal …

The Canadian Guidelines for the Management of Plaque Psoriasis were reviewed by the
entire National Psoriasis Foundation Medical Board and updated to include newly approved …

Tina Ding1, Jo Ledingham2, Raashid Luqmani3, Sarah Westlake4, Kimme Hyrich5, Mark
Lunt5, Patrick Kiely6, Marwan Bukhari7, Rikki Abernethy8, Ailsa Bosworth9, Andrew …

Several cellular functions such as apoptosis, cellular proliferation, inflammation, and
immune regulation involve the tumor necrosis factor-α (TNF)/TNF receptor (TNFR) pathway …

Background Psoriasis is a common, persistent, relapsing inflammatory skin disease that can
be associated with significant morbidity. Quality of life studies in psoriasis reveal a negative …

Worldwide, over 400 000 patients have been treated with tumour necrosis factor (TNF)-α
antagonists for indications that include rheumatoid arthritis, juvenile rheumatoid arthritis …

Understanding of the natural history and basic biology of hepatitis B virus (HBV) has
increased greatly in recent years. In view of this, the following are reviewed here:(a) recent …