Oncolytic viruses (OVs) are tumor-selective, multi-mechanistic antitumor agents. They kill
infected cancer and associated endothelial cells via direct oncolysis, and uninfected cells …

Background Central nervous system tumor (CNST) is one of the most complicated and lethal
forms of human tumors with very limited treatment options. In recent years, growing evidence …

The number of publications on mathematical modeling of cancer is growing at an
exponential rate, according to PubMed records, provided by the US National Library of …

The oncolytic features of several naturally oncolytic viruses have been shown on
Glioblastoma Multiforme cell lines and in xenotransplant models. However, orthotopic …

The book aims to provide an introduction to mathematical models that describe the
dynamics of tumor growth and the evolution of tumor cells. It can be used as a textbook for …

Clinical trials are testing oncolytic viruses (OVs) as therapies for cancer. We have shown that
animals that have brain tumors and are treated with a herpes simplex virus (HSV)-derived …

The role of the immune response to oncolytic Herpes simplex viral (oHSV) therapy for
glioblastoma is controversial because it might enhance or inhibit efficacy. We found that …

Purpose: The purpose of the present study was to investigate whether it is possible to
achieve truly systemic delivery of oncolytic reovirus, in immunocompetent hosts, using …

The Edmonston vaccine strain of measles virus has potent and selective activity against a
wide range of tumors. Tumor cells infected by this virus or genetically modified strains …

Clinical trials have proven oncolytic virotherapy to be safe but not effective. We have shown
that oncolytic viruses (OV) injected into intracranial gliomas established in rodents are …