Leveraging CRISPR gene editing technology to optimize the efficacy, safety and accessibility of CAR T-cell therapy
T Lei, Y Wang, Y Zhang, Y Yang, J Cao, J Huang… - Leukemia, 2024 - nature.com
Abstract Chimeric Antigen Receptor (CAR)-T-cell therapy has revolutionized cancer immune
therapy. However, challenges remain including increasing efficacy, reducing adverse events …
therapy. However, challenges remain including increasing efficacy, reducing adverse events …
[HTML][HTML] IGF1 receptor inhibition amplifies the effects of cancer drugs by autophagy and immune-dependent mechanisms
Q Wu, AL Tian, B Li, M Leduc, S Forveille… - … for immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Background Pharmacological autophagy enhancement constitutes a preclinically validated
strategy for preventing or treating most major age-associated diseases. Driven by this …
strategy for preventing or treating most major age-associated diseases. Driven by this …
An update on the molecular mechanism and pharmacological interventions for Ischemia-reperfusion injury by regulating AMPK/mTOR signaling pathway in autophagy
B Tang, Z Luo, R Zhang, D Zhang, G Nie, M Li, Y Dai - Cellular Signalling, 2023 - Elsevier
Abstract AMP-activated protein kinase (5'-adenosine monophosphate-activated protein
kinase, AMPK)/mammalian target of rapamycin (mTOR) is an important signaling pathway …
kinase, AMPK)/mammalian target of rapamycin (mTOR) is an important signaling pathway …
Downregulation of MYBL1 in endothelial cells contributes to atherosclerosis by repressing PLEKHM1-inducing autophagy
SA Ding, H Liu, R Zheng, Y Ge, Z Fu, J Mei… - Cell Biology and …, 2024 - Springer
MYBL1 is a strong transcriptional activator involved in the cell signaling. However, there is
no systematic study on the role of MYBL1 in atherosclerosis. The aim of this study is to …
no systematic study on the role of MYBL1 in atherosclerosis. The aim of this study is to …
The Important Roles of RTNLBs on the Function Realization of Membranous Organelles in Plant
G Cao, Y Yang, Z Tao - 2023 - researchsquare.com
Reticulons (RTNs), a class of endoplasmic reticulum binding proteins, are critical for
membrane curvature change and formation. In plants, RTNLB proteins are diverse and …
membrane curvature change and formation. In plants, RTNLB proteins are diverse and …