Biomanufacturing in low Earth orbit for regenerative medicine
Research in low Earth orbit (LEO) has become more accessible. The 2020
Biomanufacturing in Space Symposium reviewed space-based regenerative medicine …
Biomanufacturing in Space Symposium reviewed space-based regenerative medicine …
Microgravity and musculoskeletal health: what strategies should be used for a great challenge?
R Bonanni, I Cariati, M Marini, U Tarantino, V Tancredi - Life, 2023 - mdpi.com
Space colonization represents the most insidious challenge for mankind, as numerous
obstacles affect the success of space missions. Specifically, the absence of gravitational …
obstacles affect the success of space missions. Specifically, the absence of gravitational …
Regulatory networks coordinating mitochondrial quality control in skeletal muscle
MB Slavin, JM Memme, AN Oliveira… - … of Physiology-Cell …, 2022 - journals.physiology.org
The adaptive plasticity of mitochondria within a skeletal muscle is regulated by signals
converging on a myriad of regulatory networks that operate during conditions of increased …
converging on a myriad of regulatory networks that operate during conditions of increased …
Biomanufacturing of 3D tissue constructs in microgravity and their applications in human pathophysiological studies
The growing interest in bioengineering in‐vivo‐like 3D functional tissues has led to novel
approaches to the biomanufacturing process as well as expanded applications for these …
approaches to the biomanufacturing process as well as expanded applications for these …
Advanced material technologies for space and terrestrial medicine
The medical risks of spaceflight are amplified as humans venture into longer-duration and
greater-distance deep space voyages. During space missions, astronauts face the extremes …
greater-distance deep space voyages. During space missions, astronauts face the extremes …
The impact of SRT2104 on skeletal muscle mitochondrial function, redox biology, and loss of muscle mass in hindlimb unloaded rats
LT Wesolowski, JL Simons, PL Semanchik… - International Journal of …, 2023 - mdpi.com
Mechanical unloading during microgravity causes skeletal muscle atrophy and impairs
mitochondrial energetics. The elevated production of reactive oxygen species (ROS) by …
mitochondrial energetics. The elevated production of reactive oxygen species (ROS) by …
Microphysiological systems for human aging research
Recent advances in microphysiological systems (MPS), also known as organs‐on‐a‐chip
(OoC), enable the recapitulation of more complex organ and tissue functions on a smaller …
(OoC), enable the recapitulation of more complex organ and tissue functions on a smaller …
Chicken or egg? Mitochondrial phospholipids and oxidative stress in disuse-induced skeletal muscle atrophy
ER Miranda, JL Shahtout, K Funai - Antioxidants & Redox Signaling, 2023 - liebertpub.com
Significance: Accumulation of reactive oxygen species (ROS) is known to promote cellular
damage in multiple cell types. In skeletal muscle, ROS has been implicated in disuse …
damage in multiple cell types. In skeletal muscle, ROS has been implicated in disuse …
Microgravity and space medicine
D Grimm - International Journal of Molecular Sciences, 2021 - mdpi.com
This Special Issue (SI),“Microgravity and Space Medicine”, covers research articles and
reviews focusing on gravitational biology, cancer research and space medicine. It includes …
reviews focusing on gravitational biology, cancer research and space medicine. It includes …
Bioreactor development for skeletal muscle hypertrophy and atrophy by manipulating uniaxial cyclic strain: proof of concept
Skeletal muscles overcome terrestrial, gravitational loading by producing tensile forces that
produce movement through joint rotation. Conversely, the microgravity of spaceflight …
produce movement through joint rotation. Conversely, the microgravity of spaceflight …