New progress in the pharmacology of protocatechuic acid: A compound ingested in daily foods and herbs frequently and heavily

J Song, Y He, C Luo, B Feng, F Ran, H Xu, Z Ci… - Pharmacological …, 2020 - Elsevier
Protocatechuic acid is a natural phenolic acid, which widely exists in our daily diet and
herbs. It is also one of the main metabolites of complex polyphenols, such as anthocyanins …

Antidiabetic effects of simple phenolic acids: A comprehensive review

R Vinayagam, M Jayachandran, B Xu - Phytotherapy research, 2016 - Wiley Online Library
Diabetes mellitus (DM) has become a major public health threat across the globe. Current
antidiabetic therapies are based on synthetic drugs that very often have side effects. It has …

Pharmacological properties of protocatechuic acid and its potential roles as complementary medicine

Y Semaming, P Pannengpetch… - Evidence‐Based …, 2015 - Wiley Online Library
This paper reviews the reported pharmacological properties of protocatechuic acid (PCA, 3,
4‐dihydroxy benzoic acid), a type of phenolic acid found in many food plants such as olives …

A review on advanced microencapsulation technology to enhance bioavailability of phenolic compounds: Based on its activity in the treatment of Type 2 Diabetes

L Chen, C Gnanaraj, P Arulselvan, H El-Seedi… - Trends in Food Science …, 2019 - Elsevier
Background Studies on and the application of polyphenolic compounds, have recently
attracted great interest in the functional foods due to their potential health benefits to …

Phenolic acid composition, antiatherogenic and anticancer potential of honeys derived from various regions in Greece

E Spilioti, M Jaakkola, T Tolonen, M Lipponen… - PloS one, 2014 - journals.plos.org
The phenolic acid profile of honey depends greatly on its botanical and geographical origin.
In this study, we carried out a quantitative analysis of phenolic acids in the ethyl acetate …

Protocatechuic acid and human disease prevention: biological activities and molecular mechanisms

R Masella, C Santangelo, M D'archivio… - Current medicinal …, 2012 - ingentaconnect.com
Epidemiological evidence has shown that a high dietary intake of vegetables and fruit rich in
polyphenols is associated with a reduction of cancer incidence and mortality from coronary …

Hibiscus sabdariffa Polyphenolic Extract Inhibits Hyperglycemia, Hyperlipidemia, and Glycation-Oxidative Stress while Improving Insulin Resistance

CH Peng, CC Chyau, KC Chan, TH Chan… - Journal of agricultural …, 2011 - ACS Publications
H. sabdariffa polyphenolic extract (HPE) was demonstrated to inhibit high glucose-
stimulated cellular changes. In this study, we analyzed the composition of HPE and used a …

Pharmacological effects of protocatechuic acid and its therapeutic potential in neurodegenerative diseases: Review on the basis of in vitro and in vivo studies in …

K Krzysztoforska, D Mirowska-Guzel… - Nutritional …, 2019 - Taylor & Francis
Protocatechuic acid has very promising properties potentially useful in the inhibition of
neurodegenerative diseases progression. It is the main metabolite of the complex …

Protocatechuic acid abrogates oxidative insults, inflammation, and apoptosis in liver and kidney associated with monosodium glutamate intoxication in rats

RB Kassab, A Theyab, AO Al-Ghamdy… - … Science and Pollution …, 2022 - Springer
Monosodium glutamate (MSG), a commonly used flavor enhancer, has been reported to
induce hepatic and renal dysfunctions. In this study, the palliative role of protocatechuic acid …

Polyphenol compounds and PKC signaling

J Das, R Ramani, MO Suraju - … et Biophysica Acta (BBA)-General Subjects, 2016 - Elsevier
Background Naturally occurring polyphenols found in food sources provide huge health
benefits. Several polyphenolic compounds are implicated in the prevention of disease …