Protein kinases constitute one of the largest protein families in humans. 1, 2 The kinase
enzymes in this family catalyze phosphorylation of serine, threonine, or tyrosine residues …

The Aurora kinases (serine/threonine kinases) were discovered in 1995 during studies of
mutant alleles associated with abnormal spindle pole formation in Drosophila melanogaster …

Increased Aurora A expression occurs in a variety of human cancers and induces
chromosomal abnormalities during mitosis associated with tumor initiation and progression …

Aurora-A is a mitotic kinase that regulates mitotic spindle formation and segregation. In
multiple myeloma (MM), high Aurora-A gene expression has been correlated with …

The Aurora kinases have been the subject of considerable interest as targets for the
development of new anticancer agents. While evidence suggests inhibition of Aurora B …

PHA-739358 is a small-molecule 3-aminopyrazole derivative with strong activity against
Aurora kinases and cross-reactivities with some receptor tyrosine kinases relevant for …

Drugs that interfere with the normal progression of mitosis belong to the most successful
chemotherapeutic compounds currently used for anti-cancer treatment. Classically, these …

The search for new anticancer agents is considered a dynamic field of medicinal chemistry.
In recent years, the synthesis of compounds with anticancer potential has increased and a …

Aurora A kinase plays an essential role in the proper assembly and function of the mitotic
spindle, as its perturbation causes defects in centrosome separation, spindle pole …

We elucidate the molecular mechanisms of two distinct activation strategies
(autophosphorylation and TPX2-mediated activation) in human Aurora A kinase. Classic …