Oxysterols, or cholesterol oxidation products, are oxygenated derivatives of cholesterol
which are formed endogenously during the biosynthesis of bile acids and steroid hormones …

The beta amyloid protein (Aβ) plays a central role in Alzheimer's disease (AD) pathogenesis
and its interaction with cell membranes in known to promote mutually disruptive structural …

Vascular endothelial cells (ECs) sense and transduce hemodynamic shear stress into
intracellular biochemical signals, and Ca2+ signaling plays a critical role in this …

Vascular endothelial cells (ECs) sense and respond to hemodynamic shear stress, which is
critical for circulatory homeostasis and the pathophysiology of vascular diseases. The …

Timely delivery of oxygen (O2) to tissue mitochondria is so essential that elaborate
circulatory systems have evolved to minimize diffusion distances within tissue. Yet …

Cholesterol is widely known to alter the physical properties and permeability of membranes.
Several prior works have implicated cell membrane cholesterol as a barrier to tissue …

Cells must continuously monitor and couple their metabolic requirements for ATP utilization
with their ability to take up O2 for mitochondrial respiration. When O2 uptake and delivery …

A breakthrough has been discovered in pathology chemistry related to increasing molecular
structure that can interfere with oxygen diffusion through cell membranes. Free radicals can …

The senile plaque is a pathologic hallmark of Alzheimer's disease (AD). Amyloid-β peptide
(Aβ), the main constituent of senile plaques, is neurotoxic especially in its oligomeric form …

Acute respiratory distress syndrome (ARDS) affects nearly 150,000 patients per year in the
US, and is associated with high mortality (≈ 40%) and suboptimal options for patient care …