Metabolic engineering: methodologies and applications
Metabolic engineering aims to improve the production of economically valuable molecules
through the genetic manipulation of microbial metabolism. While the discipline is a little over …
through the genetic manipulation of microbial metabolism. While the discipline is a little over …
The microbiota-gut-brain axis
I. INTRODUCTION 1877 II. STUDYING THE... 1881 III. MICROBIOTA-GUT-BRAIN AXIS...
1907 IV. PATHWAYS OF COMMUNICATION 1911 V. MICROBIOTA AND SYNAPTIC... 1929 …
1907 IV. PATHWAYS OF COMMUNICATION 1911 V. MICROBIOTA AND SYNAPTIC... 1929 …
Genome-scale metabolic reconstruction of 7,302 human microorganisms for personalized medicine
The human microbiome influences the efficacy and safety of a wide variety of commonly
prescribed drugs. Designing precision medicine approaches that incorporate microbial …
prescribed drugs. Designing precision medicine approaches that incorporate microbial …
[HTML][HTML] Metabolic modeling of single Th17 cells reveals regulators of autoimmunity
Metabolism is a major regulator of immune cell function, but it remains difficult to study the
metabolic status of individual cells. Here, we present Compass, an algorithm to characterize …
metabolic status of individual cells. Here, we present Compass, an algorithm to characterize …
Ecological modelling approaches for predicting emergent properties in microbial communities
NI van den Berg, D Machado, S Santos… - Nature ecology & …, 2022 - nature.com
Recent studies have brought forward the critical role of emergent properties in shaping
microbial communities and the ecosystems of which they are a part. Emergent properties …
microbial communities and the ecosystems of which they are a part. Emergent properties …
Emerging therapies in cancer metabolism
Y Xiao, TJ Yu, Y Xu, R Ding, YP Wang, YZ Jiang… - Cell Metabolism, 2023 - cell.com
Metabolic reprogramming in cancer is not only a biological hallmark but also reveals
treatment vulnerabilities. Numerous metabolic molecules have shown promise as treatment …
treatment vulnerabilities. Numerous metabolic molecules have shown promise as treatment …
Identification of bioactive metabolites using activity metabolomics
The metabolome, the collection of small-molecule chemical entities involved in metabolism,
has traditionally been studied with the aim of identifying biomarkers in the diagnosis and …
has traditionally been studied with the aim of identifying biomarkers in the diagnosis and …
Common principles and best practices for engineering microbiomes
Despite broad scientific interest in harnessing the power of Earth's microbiomes, knowledge
gaps hinder their efficient use for addressing urgent societal and environmental challenges …
gaps hinder their efficient use for addressing urgent societal and environmental challenges …
Systems biology and multi-omics integration: viewpoints from the metabolomics research community
The use of multiple omics techniques (ie, genomics, transcriptomics, proteomics, and
metabolomics) is becoming increasingly popular in all facets of life science. Omics …
metabolomics) is becoming increasingly popular in all facets of life science. Omics …
Reconstructing organisms in silico: genome-scale models and their emerging applications
X Fang, CJ Lloyd, BO Palsson - Nature Reviews Microbiology, 2020 - nature.com
Escherichia coli is considered to be the best-known microorganism given the large number
of published studies detailing its genes, its genome and the biochemical functions of its …
of published studies detailing its genes, its genome and the biochemical functions of its …