Mitochondrial diabetes (MD) is generally classified as a genetic defect of β-cells. The main
pathophysiology is insulin secretion failure in pancreatic β-cells due to impaired …

Simple Summary The mitochondrial genome is a multicopy circular DNA with high mutation
rates due to replication and repair errors. Mitochondrial DNA (mtDNA) heteroplasmy refers …

Several mitochondrial tRNA mutations have been associated with maternally inherited
diabetes and deafness. However, the pathophysiology of these tRNA mutations remains …

The gradual ageing of the world population has been accompanied by a dramatic increase
in the prevalence of obesity and metabolic diseases, especially type 2 diabetes. The …

Although a majority of children and adults with diabetes mellitus (DM) are diagnosed with
type 1 diabetes mellitus (T1D) or type 2 diabetes mellitus (T2D), a significant number of …

Context: Mitochondrial diabetes is a rare form of diabetes mellitus accounting for up to 1% of
all diabetes. Pyruvate therapy has been reported to be a potential therapeutic choice for …

Mitochondrial diabetes (MD) is a heterogeneous disorder characterized by a chronic
hyperglycemia, maternal transmission and its association with a bilateral hearing …

In this report, we investigate molecular pathogenic mechanism of a diabetes-associated
homoplasmic mitochondrial tRNA mutation in a Han Chinese family with maternally …

Mitochondrial diseases are a clinically heterogeneous group of disorders that arise as a
result of dysfunction of the mitochondrial respiratory chain. They can be caused by mutations …

Maternally inherited diabetes and deafness (MIDD) is a mitochondrial syndrome
characterized by the onset of sensorineural hearing loss and diabetes in adults. Some …